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Tbio
ANKLE2
Ankyrin repeat and LEM domain-containing protein 2

Protein Summary
Description
Involved in mitotic nuclear envelope reassembly by promoting dephosphorylation of BAF/BANF1 during mitotic exit. Coordinates the control of BAF/BANF1 dephosphorylation by inhibiting VRK1 kinase and promoting dephosphorylation of BAF/BANF1 by protein phosphatase 2A (PP2A), thereby facilitating nuclear envelope assembly. It is unclear whether it acts as a real PP2A regulatory subunit or whether it is involved in recruitment of the PP2A complex. Involved in brain development (PubMed:25259927). This gene encodes a member of the LEM family of inner nuclear membrane proteins. The encoded protein functions as a mitotic regulator through postmitotic formation of the nuclear envelope. Mutations in this gene cause morphology defects in the nuclear envelope and BAF hyperphosphorylation. [provided by RefSeq, Mar 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357997
  • ENSP00000350686
  • ENSG00000176915
  • ENST00000542282
  • ENSP00000437807
  • ENST00000542657
  • ENSP00000438551

Symbol
  • KIAA0692
  • LEM4
  • Lem4
  • LEMD7
  • MCPH16
  • KIAA0692
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor binding site profile
0.8
transcription factor perturbation
0.74
histone modification site profile
0.73
protein domain
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.25   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.25   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
15.7
monocyte count
1
1
1
15.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
15.7
monocyte count
1
15.7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1261856
71782
Rat
RGD:1310191
360829
Dog
ankyrin repeat and LEM domain containing 2
VGNC:37876
609795
Horse
ankyrin repeat and LEM domain containing 2
VGNC:15315
100061570
Cow
ankyrin repeat and LEM domain containing 2
VGNC:25904
540159
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ankyrin repeat and LEM domain containing 2
Horse
ankyrin repeat and LEM domain containing 2
Cow
ankyrin repeat and LEM domain containing 2
Pathways (7)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Initiation of Nuclear Envelope Reformation
Reactome
M Phase
Reactome
Mitotic Anaphase
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Initiation of Nuclear Envelope Reformation
M Phase
Mitotic Anaphase
Protein-Protein Interactions (60)
1 – 10 of 60
NUDT11
Tbio
Family: Enzyme
Novelty: 0.19004372
p_int: 0.999999699
p_ni: 5e-9
p_wrong: 2.96e-7
Data Source: BioPlex
PPP2R1A
Tbio
Family: Enzyme
Novelty: 0.01134139
p_int: 0.999999538
p_ni: 4.45e-7
p_wrong: 1.7e-8
Score: 0.392
Data Source: BioPlex,STRINGDB
PPP2CB
Tbio
Family: Enzyme
Novelty: 0.0483178
p_int: 0.99999576
p_ni: 0.00000424
Score: 0.254
Data Source: BioPlex,STRINGDB
GLMN
Tbio
Novelty: 0.01940401
p_int: 0.999994936
p_ni: 0.000005049
p_wrong: 1.5e-8
Score: 0.16
Data Source: BioPlex,STRINGDB
STAC
Tbio
Novelty: 0.01982527
p_int: 0.999956346
p_ni: 0.000043654
Score: 0.252
Data Source: BioPlex,STRINGDB
STAC3
Tbio
Novelty: 0.03431498
p_int: 0.999909167
p_ni: 0.000090827
p_wrong: 6e-9
Score: 0.252
Data Source: BioPlex,STRINGDB
PDGFRB
Tclin
Family: Kinase
Novelty: 0.00074896
p_int: 0.999838575
p_ni: 0.000161425
Data Source: BioPlex
MTHFR
Tbio
Family: Enzyme
Novelty: 0.00018162
p_int: 0.999795447
p_ni: 0.000204547
p_wrong: 6e-9
Data Source: BioPlex
NUDT4
Tbio
Family: Enzyme
Novelty: 0.05544881
p_int: 0.999297742
p_ni: 0.000001598
p_wrong: 0.00070066
Data Source: BioPlex
IL4R
Tclin
Novelty: 0.00359183
p_int: 0.998944033
p_ni: 0.001055967
Data Source: BioPlex
Publication Statistics
PubMed Score  10.25

PubMed score by year
PubTator Score  5.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer