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Tchem
PHF8
Histone lysine demethylase PHF8

Protein Summary
Description
Histone lysine demethylase with selectivity for the di- and monomethyl states that plays a key role cell cycle progression, rDNA transcription and brain development. Demethylates mono- and dimethylated histone H3 'Lys-9' residue (H3K9Me1 and H3K9Me2), dimethylated H3 'Lys-27' (H3K27Me2) and monomethylated histone H4 'Lys-20' residue (H4K20Me1). Acts as a transcription activator as H3K9Me1, H3K9Me2, H3K27Me2 and H4K20Me1 are epigenetic repressive marks. Involved in cell cycle progression by being required to control G1-S transition. Acts as a coactivator of rDNA transcription, by activating polymerase I (pol I) mediated transcription of rRNA genes. Required for brain development, probably by regulating expression of neuron-specific genes. Only has activity toward H4K20Me1 when nucleosome is used as a substrate and when not histone octamer is used as substrate. May also have weak activity toward dimethylated H3 'Lys-36' (H3K36Me2), however, the relevance of this result remains unsure in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322659
  • ENSP00000319473
  • ENSG00000172943
  • ENST00000338154
  • ENSP00000338868
  • ENST00000338946
  • ENSP00000340051
  • ENST00000357988
  • ENSP00000350676

Symbol
  • KIAA1111
  • ZNF422
  • KDM7B
  • JHDM1F
  • MRXSSD
  • ZNF422
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.95
microRNA
0.89
protein domain
0.85
molecular function
0.81
biological process
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.33   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.33   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
87.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
87.5
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
PHD finger protein 8
703633
Mouse
MGI:2444341
320595
Rat
RGD:1561065
317425
Dog
PHD finger protein 8
VGNC:44494
491897
Horse
PHD finger protein 8
VGNC:21387
100060410
Species
Name
OMA
EggNOG
Inparanoid
Macaque
PHD finger protein 8
Mouse
Rat
Dog
PHD finger protein 8
Horse
PHD finger protein 8
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9UPP1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
Condensation of Prophase Chromosomes
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Chromatin modifying enzymes
Chromatin organization
Condensation of Prophase Chromosomes
Gene Ontology Terms (23)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (128)
1 – 10 of 128
TOPBP1
Tbio
Family: Enzyme
Novelty: 0.00735579
p_int: 0.999999755
p_ni: 9.8e-8
p_wrong: 1.47e-7
Data Source: BioPlex
MAPK14
Tchem
Family: Kinase
Novelty: 0.00045138
p_int: 0.999994438
p_ni: 0.000005563
Data Source: BioPlex
CCNA2
Tchem
Novelty: 0.00049887
p_int: 0.999991848
p_ni: 0.000008134
p_wrong: 1.9e-8
Score: 0.291
Data Source: BioPlex,STRINGDB
MAGEA10
Tbio
Novelty: 0.05364393
p_int: 0.999977611
p_ni: 0.000022389
Score: 0.187
Data Source: BioPlex,STRINGDB
ZNF653
Tbio
Family: TF
Novelty: 1.467544
p_int: 0.999172034
p_ni: 0.000735112
p_wrong: 0.000092854
Data Source: BioPlex
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
p_int: 0.999015626
p_ni: 0.000984374
Score: 0.174
Data Source: BioPlex,STRINGDB
RNF138
Tbio
Family: TF
Novelty: 0.07543428
p_int: 0.99068651
p_ni: 0.009313419
p_wrong: 7e-8
Data Source: BioPlex
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.988578976
p_ni: 0.011421007
p_wrong: 1.7e-8
Data Source: BioPlex
CKS2
Tbio
Family: Enzyme
Novelty: 0.02482411
p_int: 0.987440319
p_ni: 0.001098504
p_wrong: 0.011461177
Data Source: BioPlex
MAD2L1BP
Tbio
Novelty: 0.48374717
p_int: 0.98603074
p_ni: 0.013967862
p_wrong: 0.000001397
Data Source: BioPlex
Publication Statistics
PubMed Score  63.33

PubMed score by year
PubTator Score  32.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer