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Tbio
CHM
Rab proteins geranylgeranyltransferase component A 1

Protein Summary
Description
Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation. This gene encodes component A of the RAB geranylgeranyl transferase holoenzyme. In the dimeric holoenzyme, this subunit binds unprenylated Rab GTPases and then presents them to the catalytic Rab GGTase subunit for the geranylgeranyl transfer reaction. Rab GTPases need to be geranylgeranyled on either one or two cysteine residues in their C-terminus to localize to the corre ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357749
  • ENSP00000350386
  • ENSG00000188419
  • ENST00000615443
  • ENSP00000484306

Symbol
  • REP1
  • TCD
  • TCD
  • GGTA
  • REP-1
  • DXS540
  • HSD-32
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
molecular function
0.73
small molecule perturbation
0.73
microRNA
0.65
tissue sample
0.64


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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.1   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 154   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 448.1   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CHM, Rab escort protein 1
VGNC:8328
465737
Macaque
CHM, Rab escort protein 1
694499
Mouse
MGI:892979
12662
Rat
RGD:2340
24942
Dog
CHM, Rab escort protein 1
VGNC:39220
480972
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CHM, Rab escort protein 1
Macaque
CHM, Rab escort protein 1
Mouse
Rat
Dog
CHM, Rab escort protein 1
Pathways (13)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Membrane Trafficking
Metabolism of proteins
Post-translational protein modification
Protein-Protein Interactions (163)
1 – 10 of 163
RAB6B
Tbio
Family: Enzyme
Novelty: 0.0865097
p_int: 0.999999406
p_ni: 5.93e-7
Score: 0.939
Data Source: BioPlex,STRINGDB
RAB31
Tbio
Family: Enzyme
Novelty: 0.03673084
p_int: 0.9999986
p_ni: 0.0000014
Score: 0.966
Data Source: BioPlex,Reactome,STRINGDB
RAB5A
Tbio
Family: Enzyme
Novelty: 0.00111347
p_int: 0.999998547
p_ni: 0.000001453
Score: 0.977
Data Source: BioPlex,Reactome,STRINGDB
RAB2B
Tdark
Family: Enzyme
Novelty: 0.18567584
p_int: 0.999998083
p_ni: 0.000001917
Score: 0.922
Data Source: BioPlex,STRINGDB
RAB27A
Tchem
Family: Enzyme
Novelty: 0.00369416
p_int: 0.999989677
p_ni: 0.000010323
Score: 0.959
Data Source: BioPlex,Reactome,STRINGDB
RAB7B
Tbio
Family: Enzyme
Novelty: 0.00207354
p_int: 0.99997953
p_ni: 0.000020469
p_wrong: 1e-9
Score: 0.984
Data Source: BioPlex,STRINGDB
RAB8B
Tbio
Family: Enzyme
Novelty: 0.06230082
p_int: 0.999979238
p_ni: 0.000020758
p_wrong: 5e-9
Score: 0.938
Data Source: BioPlex,STRINGDB
RAB9A
Tbio
Family: Enzyme
Novelty: 0.07006531
p_int: 0.999974827
p_ni: 0.000008962
p_wrong: 0.00001621
Score: 0.955
Data Source: BioPlex,Reactome,STRINGDB
RAB30
Tbio
Family: Enzyme
Novelty: 0.1262404
p_int: 0.99996602
p_ni: 0.00003398
Score: 0.922
Data Source: BioPlex,STRINGDB
RAB3A
Tbio
Family: Enzyme
Novelty: 0.0043532
p_int: 0.999965688
p_ni: 0.000034312
Score: 0.97
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  448.10

PubMed score by year
PubTator Score  346.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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