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Tbio
ETFBKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

Protein Classes
Protein Summary
Description
Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781). Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357721
  • ENSP00000350353
  • ENSG00000139160
  • ENST00000395763
  • ENSP00000379112
  • ENST00000412352
  • ENSP00000396123
  • ENST00000538463
  • ENSP00000441421

Symbol
  • C12orf72
  • METTL20
  • METTL20
  • C12orf72
  • ETFB-KMT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.17   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.17   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (3)
Metabolism of proteins (R-HSA-392499)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Protein methylation
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Post-translational protein modification
Protein methylation
Protein-Protein Interactions (65)
1 – 10 of 65
SELENOO
Tdark
Novelty: 0.02959704
p_int: 0.967656613
p_ni: 0.032343068
p_wrong: 3.19e-7
Score: 0.295
Data Source: BioPlex,STRINGDB
HSPD1
Tbio
Novelty: 0.00018924
p_int: 0.930274729
p_ni: 0.069725271
Score: 0.235
Data Source: BioPlex,STRINGDB
CLPX
Tbio
Family: Enzyme
Novelty: 0.00254331
p_int: 0.757936213
p_ni: 0.242063787
Score: 0.232
Data Source: BioPlex,STRINGDB
ETFB
Tbio
Novelty: 0.02010772
Score: 0.955
Data Source: Reactome,STRINGDB
METTL21A
Tbio
Family: Enzyme
Novelty: 0.31897774
Score: 0.86
Data Source: STRINGDB
VCPKMT
Tbio
Family: Enzyme
Novelty: 0.37849297
Score: 0.849
Data Source: STRINGDB
NDUFAF7
Tbio
Family: Enzyme
Novelty: 0.24691414
Score: 0.843
Data Source: STRINGDB
METTL18
Tdark
Family: Enzyme
Novelty: 0.3377377
Score: 0.842
Data Source: STRINGDB
EEF1AKMT2
Tbio
Family: Enzyme
Novelty: 0.13586312
Score: 0.811
Data Source: STRINGDB
MTRF1L
Tbio
Family: Enzyme
Novelty: 0.08598685
Score: 0.794
Data Source: STRINGDB
Publication Statistics
PubMed Score  3.17

PubMed score by year
PubTator Score  1.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer