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Tchem
BMX
Cytoplasmic tyrosine-protein kinase BMX

Protein Summary
Description
Non-receptor tyrosine kinase that plays central but diverse modulatory roles in various signaling processes involved in the regulation of actin reorganization, cell migration, cell proliferation and survival, cell adhesion, and apoptosis. Participates in signal transduction stimulated by growth factor receptors, cytokine receptors, G-protein coupled receptors, antigen receptors and integrins. Induces tyrosine phosphorylation of BCAR1 in response to integrin regulation. Activation of BMX by integrins is mediated by PTK2/FAK1, a key mediator of integrin signaling events leading to the regulation of actin cytoskeleton and cell motility. Plays a critical role in TNF-induced angiogenesis, and implicated in the signaling of TEK and FLT1 receptors, 2 important receptor families essential for angiogenesis. Required for the phosphorylation and activation of STAT3, a transcription factor involved in cell differentiation. Also involved in interleukin-6 (IL6) induced differentiation. Plays also a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342014
  • ENSP00000340082
  • ENSG00000102010
  • ENST00000348343
  • ENSP00000308774
  • ENST00000357607
  • ENSP00000350224

Symbol
  • ETK
  • PSCTK2
  • PSCTK3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.97
hub protein
0.88
gene perturbation
0.81
kinase
0.78


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.62   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 591   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 267.62   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 591   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptotic cleavage of cellular proteins
Reactome
Apoptotic execution phase
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptotic cleavage of cellular proteins
Apoptotic execution phase
Metabolism
Metabolism of lipids
Protein-Protein Interactions (51)
1 – 10 of 51
CC2D1B
Tbio
Novelty: 0.22031767
p_int: 0.999999954
p_ni: 3.1e-8
p_wrong: 1.5e-8
Score: 0.552
Data Source: BioPlex,STRINGDB
USP24
Tbio
Family: Enzyme
Novelty: 0.07281326
p_int: 0.999999917
p_ni: 8.3e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
ARIH2
Tbio
Family: Enzyme
Novelty: 0.03455224
p_int: 0.999957772
p_ni: 0.000042194
p_wrong: 3.4e-8
Score: 0.235
Data Source: BioPlex,STRINGDB
KIZ
Tbio
Novelty: 0.0644373
p_int: 0.999472383
p_ni: 0.000527602
p_wrong: 1.5e-8
Score: 0.209
Data Source: BioPlex,STRINGDB
WDR45B
Tbio
Novelty: 0.22407227
p_int: 0.986659197
p_ni: 0.013340803
Score: 0.167
Data Source: BioPlex,STRINGDB
PRDM1
Tbio
Family: TF; Epigenetic
Novelty: 0.00224931
p_int: 0.981743669
p_ni: 0.018256331
Score: 0.24
Data Source: BioPlex,STRINGDB
PDCD2L
Tbio
Novelty: 0.33193498
p_int: 0.970161404
p_ni: 0.029837919
p_wrong: 6.77e-7
Score: 0.169
Data Source: BioPlex,STRINGDB
COPS8
Tbio
Novelty: 0.0408885
p_int: 0.822590463
p_ni: 0.177409537
Score: 0.203
Data Source: BioPlex,STRINGDB
RUFY1
Tbio
Novelty: 0.16796947
Score: 0.965
Data Source: Reactome,STRINGDB
PTK2
Tclin
Family: Kinase
Novelty: 0.00066622
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  267.62

PubMed score by year
PubTator Score  134.97

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer