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Tchem
GIP
Gastric inhibitory polypeptide

Protein Classes
Protein Summary
Description
Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion. This gene encodes an incretin hormone and belongs to the glucagon superfamily. The encoded protein is important in maintaining glucose homeostasis as it is a potent stimulator of insulin secretion from pancreatic beta-cells following food ingestion and nutrient absorption. This gene stimulates insulin secretion via its G protein-coupled receptor activation of adenylyl cyclase and other signal transduction pathways. It is a relatively poor inhibitor of gastric acid secretion. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357424
  • ENSP00000350005
  • ENSG00000159224
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.82
cell type or tissue
0.75
biological term
0.69
cell line
0.59
PubMedID
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 826.93   (req: < 5)
Gene RIFs: 63   (req: <= 3)
Antibodies: 328   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 826.93   (req: >= 5)
Gene RIFs: 63   (req: > 3)
Antibodies: 328   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL499372
chemical structure image
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
66.7
3
1
2
1.1
47.4
2
2
2
31.1
household income
1
1
1
22.6
C-reactive protein measurement
1
1
1
13.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
66.7
2
1.1
47.4
2
31.1
household income
1
22.6
C-reactive protein measurement
1
13.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
gastric inhibitory polypeptide
VGNC:9297
749143
Mouse
MGI:107504
14607
Rat
RGD:2709
25040
Dog
gastric inhibitory polypeptide
VGNC:41224
100856162
Cow
gastric inhibitory polypeptide
VGNC:29364
511073
Species
Name
OMA
EggNOG
Inparanoid
Chimp
gastric inhibitory polypeptide
Mouse
Rat
Dog
gastric inhibitory polypeptide
Cow
gastric inhibitory polypeptide
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P09681-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (20)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Glucagon-type ligand receptors
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Glucagon-type ligand receptors
Gene Ontology Terms (33)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (207)
1 – 10 of 207
CFAP410
Tbio
Novelty: 0.0143773
p_int: 0.999930024
p_ni: 0.000060098
p_wrong: 0.000009878
Data Source: BioPlex
ARNT
Tbio
Family: TF
Novelty: 0.00183071
p_int: 0.999783296
p_ni: 0.000216704
Data Source: BioPlex
ELOA2
Tdark
Family: Enzyme
Novelty: 0.7420148
p_int: 0.999490906
p_ni: 0.000509042
p_wrong: 5.2e-8
Data Source: BioPlex
CALCB
Tclin
Novelty: 0.02069808
p_int: 0.997104137
p_ni: 8.67e-7
p_wrong: 0.002894996
Score: 0.9
Data Source: BioPlex,STRINGDB
UXS1
Tbio
Family: Enzyme
Novelty: 0.04671281
p_int: 0.996841671
p_ni: 0.003158329
Data Source: BioPlex
COL14A1
Tbio
Novelty: 0.01760399
p_int: 0.995580298
p_ni: 0.004419701
p_wrong: 2e-9
Score: 0.19
Data Source: BioPlex,STRINGDB
TTC4
Tbio
Novelty: 0.00808711
p_int: 0.994407651
p_ni: 0.005592349
Data Source: BioPlex
TMEM130
Tdark
Novelty: 1.39618601
p_int: 0.987623937
p_ni: 4e-9
p_wrong: 0.01237606
Data Source: BioPlex
LACRT
Tbio
Novelty: 0.03333799
p_int: 0.972202776
p_ni: 0.025249579
p_wrong: 0.002547645
Data Source: BioPlex
CALCA
Tclin
Novelty: 0.00010496
p_int: 0.970012506
p_ni: 0.029987236
p_wrong: 2.58e-7
Score: 0.942
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  826.93

PubMed score by year
PubTator Score  899.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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