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Tchem
CCRL2
C-C chemokine receptor-like 2

Protein Summary
Description
Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses. This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357392
  • ENSP00000349967
  • ENSG00000121797
  • ENST00000399036
  • ENSP00000381994
  • ENST00000400880
  • ENSP00000383677
  • ENST00000400882
  • ENSP00000383678

Symbol
  • CCR11
  • CCR6
  • CKRX
  • CRAM
  • HCR
  • HCR
  • CKRX
  • CRAM
  • ACKR5
  • CRAM-A
  • CRAM-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.7
transcription factor
0.69
molecular function
0.67
PubMedID
0.62
gene perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.31   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 405   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 301.31   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 405   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 93
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
74.8
viral load
1
1
1
57.6
HIV-1 infection
1
1
1
57.6
macrophage inflammatory protein 1b measurement
1
1
1
33.9
CCL4 measurement
1
1
1
33.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
74.8
viral load
1
57.6
HIV-1 infection
1
57.6
macrophage inflammatory protein 1b measurement
1
33.9
CCL4 measurement
1
33.4
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor like 2
VGNC:11368
460324
Macaque
C-C motif chemokine receptor like 2
713715
Mouse
MGI:1920904
54199
Rat
RGD:1311811
316019
Dog
C-C motif chemokine receptor like 2
VGNC:38918
484788
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-C motif chemokine receptor like 2
Macaque
C-C motif chemokine receptor like 2
Mouse
Rat
Dog
C-C motif chemokine receptor like 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O00421-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
GPCR ligand binding
Peptide ligand-binding receptors
Signal Transduction
Gene Ontology Terms (17)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (179)
1 – 10 of 179
CST1
Tbio
Novelty: 0.02399609
p_int: 0.965158893
p_ni: 0.034369118
p_wrong: 0.000471989
Score: 0.666
Data Source: BioPlex,STRINGDB
CST4
Tbio
Novelty: 0.00773554
p_int: 0.912844182
p_ni: 0.086235973
p_wrong: 0.000919845
Score: 0.638
Data Source: BioPlex,STRINGDB
FITM2
Tdark
Novelty: 0.01882177
p_int: 0.886192516
p_ni: 0.098474667
p_wrong: 0.015332816
Score: 0.189
Data Source: BioPlex,STRINGDB
AMY1A
Tchem
Family: Enzyme
Novelty: 0.00210045
p_int: 0.879529579
p_ni: 0.120470383
p_wrong: 3.8e-8
Data Source: BioPlex
IGHA1
Tbio
p_int: 0.809001025
p_ni: 0.190998975
Data Source: BioPlex
CCL19
Tbio
Novelty: 0.00169711
Score: 0.966
Data Source: Reactome,STRINGDB
CCL20
Tbio
Novelty: 0.00158263
Score: 0.938
Data Source: STRINGDB
RARRES2
Tbio
Novelty: 0.0029178
Score: 0.831
Data Source: STRINGDB
TNF
Tclin
Novelty: 0.00001457
Score: 0.816
Data Source: STRINGDB
IL10
Tbio
Novelty: 0.00004352
Score: 0.801
Data Source: STRINGDB
Publication Statistics
PubMed Score  301.31

PubMed score by year
PubTator Score  141.77

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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