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Tbio
ACTB
Actin, cytoplasmic 1

Protein Summary
Description
Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells (PubMed:29581253). Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction (PubMed:29581253). In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA (PubMed:29925947). This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patie ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331789
  • ENSP00000349960
  • ENSG00000075624
  • ENST00000493945
  • ENSP00000494269
  • ENST00000646664
  • ENSP00000494750

Symbol
  • BRWS1
  • PS1TP5BP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
molecular function
1
protein complex
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9460.64   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 1721   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9460.64   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 1721   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
61.5
lymphocyte count
1
1
1
54.8
electrocardiography
1
1
1
35.8
triglyceride measurement
1
1
1
19.9
reticulocyte measurement
1
1
1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
61.5
lymphocyte count
1
54.8
electrocardiography
1
35.8
triglyceride measurement
1
19.9
reticulocyte measurement
1
18.8
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (173)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 35
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
B-WICH complex positively regulates rRNA expression
Reactome
Chaperonin-mediated protein folding
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Name
Explore in Pharos
Explore in Source
Axon guidance
B-WICH complex positively regulates rRNA expression
Chaperonin-mediated protein folding
Chromatin modifying enzymes
Chromatin organization
Gene Ontology Terms (49)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
SynGO
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (889)
1 – 10 of 889
POTEKP
Tdark
p_int: 0.999999995
p_ni: 2e-9
p_wrong: 3e-9
Data Source: BioPlex
POTEI
Tdark
Novelty: 0.41311202
p_int: 0.999999982
p_ni: 1.8e-8
Data Source: BioPlex
SPIRE1
Tbio
Novelty: 0.04929601
p_int: 0.999999862
p_ni: 1.38e-7
Score: 0.45
Data Source: BioPlex,STRINGDB
SPIRE2
Tbio
Novelty: 0.06697946
p_int: 0.999999137
p_ni: 8.58e-7
p_wrong: 6e-9
Score: 0.423
Data Source: BioPlex,STRINGDB
KLHL7
Tbio
Novelty: 0.0522116
p_int: 0.999649249
p_ni: 0.000176517
p_wrong: 0.000174234
Data Source: BioPlex
LRRC20
Tdark
Novelty: 3.82267008
p_int: 0.999578029
p_ni: 0.000421971
Data Source: BioPlex
ACTA2
Tbio
Novelty: 0.00199354
p_int: 0.999330741
p_ni: 0.000669259
Score: 0.563
Data Source: BioPlex,STRINGDB
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.999201974
p_ni: 0.000798026
Score: 0.946
Data Source: BioPlex,STRINGDB
MAP3K4
Tbio
Family: Kinase
Novelty: 0.02186397
p_int: 0.998997672
p_ni: 0.001002328
Score: 0.231
Data Source: BioPlex,STRINGDB
GC
Tchem
Novelty: 0.00065382
p_int: 0.998831261
p_ni: 0.001168739
Score: 0.286
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9460.64

PubMed score by year
PubTator Score  141.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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