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Tbio
ANK2
Ankyrin-2

Protein Summary
Description
Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Ass ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357077
  • ENSP00000349588
  • ENSG00000145362
  • ENST00000394537
  • ENSP00000378044
  • ENST00000506722
  • ENSP00000421067
  • ENST00000510275
  • ENSP00000421023

Symbol
  • ANKB
  • LQT4
  • ANK-2
  • brank-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
biological process
0.98
hub protein
0.94
kinase
0.9
cellular component
0.89


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.39   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.39   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
94.3
nitric oxide exhalation measurement
1
1
1
66.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
94.3
nitric oxide exhalation measurement
1
66.2
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Axon guidance
Reactome
COPI-mediated anterograde transport
Reactome
Developmental Biology
Reactome
ER to Golgi Anterograde Transport
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Axon guidance
COPI-mediated anterograde transport
Developmental Biology
ER to Golgi Anterograde Transport
Gene Ontology Terms (70)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (257)
1 – 10 of 257
PALM2
Tbio
Novelty: 0.03469098
p_int: 0.999996185
p_ni: 0.000003815
Score: 0.238
Data Source: BioPlex,STRINGDB
RAPGEF5
Tbio
Novelty: 0.02449802
p_int: 0.999993677
p_ni: 0.000006321
p_wrong: 2e-9
Score: 0.269
Data Source: BioPlex,STRINGDB
CHL1
Tbio
Novelty: 0.00055237
p_int: 0.999971248
p_ni: 0.000028752
Score: 0.64
Data Source: BioPlex,STRINGDB
BTF3
Tbio
Novelty: 0.01198537
p_int: 0.999886681
p_ni: 0.000113318
p_wrong: 1e-9
Data Source: BioPlex
PPP1R12B
Tbio
Family: Enzyme
Novelty: 0.0424259
p_int: 0.999149744
p_ni: 0.000850018
p_wrong: 2.38e-7
Data Source: BioPlex
MAPK8IP1
Tbio
Family: Enzyme
Novelty: 0.00284875
p_int: 0.992460769
p_ni: 0.007539231
Score: 0.284
Data Source: BioPlex,STRINGDB
NUFIP1
Tbio
Novelty: 0.11726869
p_int: 0.990265445
p_ni: 0.009734555
Data Source: BioPlex
HIF1AN
Tbio
Novelty: 0.00861018
p_int: 0.964420245
p_ni: 0.035579754
Score: 0.235
Data Source: BioPlex,STRINGDB
DNAAF2
Tbio
Novelty: 0.01254416
p_int: 0.951917758
p_ni: 0.048082242
Score: 0.161
Data Source: BioPlex,STRINGDB
HAX1
Tbio
Novelty: 0.00749205
p_int: 0.871556191
p_ni: 0.128443809
Data Source: BioPlex
Publication Statistics
PubMed Score  207.39

PubMed score by year
PubTator Score  84.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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