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Tbio
GUCA2A
Guanylin

Protein Summary
Description
Endogenous activator of intestinal guanylate cyclase. It stimulates this enzyme through the same receptor binding region as the heat-stable enterotoxins.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357001
  • ENSP00000349493
  • ENSG00000197273

Symbol
  • GUCA2
  • GUCA2
  • STARA
  • GCAP-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.78
gene perturbation
0.63
tissue
0.56
PubMedID
0.48
cell line
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.29   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 170   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.29   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 170   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (57)
Digestion (R-HSA-8935690)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Digestion
Reactome
Digestion and absorption
Name
Explore in Pharos
Explore in Source
Digestion
Digestion and absorption
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (73)
1 – 10 of 73
GUCY2C
Tclin
Family: Kinase
Novelty: 0.0020599
Score: 0.994
Data Source: Reactome,STRINGDB
NPR3
Tchem
Novelty: 0.00281298
Score: 0.86
Data Source: STRINGDB
TMIGD1
Tdark
Novelty: 0.22857143
Score: 0.837
Data Source: STRINGDB
EMD
Tbio
Novelty: 0.00152727
Score: 0.8
Data Source: STRINGDB
GUCA2B
Tbio
Family: Enzyme
Novelty: 0.04198416
Score: 0.736
Data Source: STRINGDB
GUCA1A
Tbio
Family: Enzyme
Novelty: 0.01070141
Score: 0.728
Data Source: STRINGDB
CYREN
Tbio
Novelty: 0.0052779
Score: 0.718
Data Source: STRINGDB
GUCY2D
Tbio
Family: Kinase
Novelty: 0.00605584
Score: 0.7
Data Source: STRINGDB
CFTR
Tclin
Family: IC
Novelty: 0.00015058
Score: 0.681
Data Source: STRINGDB
CLCA1
Tbio
Family: IC
Novelty: 0.01247111
Score: 0.676
Data Source: STRINGDB
Publication Statistics
PubMed Score  97.29

PubMed score by year
PubTator Score  117.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer