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Tbio
ATN1
Atrophin-1

Protein Summary
Description
Transcriptional corepressor. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation (By similarity). Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of poly-Gln (polyQ) repeats. Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356654
  • ENSP00000349076
  • ENSG00000111676
  • ENST00000396684
  • ENSP00000379915

Symbol
  • D12S755E
  • DRPLA
  • B37
  • HRS
  • NOD
  • DRPLA
  • D12S755E
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.86
hub protein
0.85
transcription factor binding site profile
0.76
cell line
0.72
kinase
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.09   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 135   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 74.09   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 135   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
atrophin 1
722114
Mouse
MGI:104725
13498
Rat
RGD:6491795
100911672
Dog
atrophin 1
VGNC:38234
611607
Horse
atrophin 1 [Source:HGNC Symbol;Acc:HGNC:3033]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
atrophin 1
Mouse
Rat
Dog
atrophin 1
Horse
atrophin 1 [Source:HGNC Symbol;Acc:HGNC:3033]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P54259-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Intracellular signaling by second messengers (R-HSA-9006925)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Intracellular signaling by second messengers
Reactome
PIP3 activates AKT signaling
Reactome
PTEN Regulation
Reactome
Regulation of PTEN gene transcription
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Intracellular signaling by second messengers
PIP3 activates AKT signaling
PTEN Regulation
Regulation of PTEN gene transcription
Signal Transduction
Protein-Protein Interactions (143)
1 – 10 of 143
WDR5
Tchem
Novelty: 0.0059945
p_int: 0.999999998
p_wrong: 2e-9
Score: 0.273
Data Source: BioPlex,STRINGDB
NR2E1
Tbio
Family: NR
Novelty: 0.0184868
Score: 0.98
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.951
Data Source: STRINGDB
KDM1A
Tchem
Family: Epigenetic
Novelty: 0.00142673
Score: 0.946
Data Source: STRINGDB
HDAC3
Tclin
Family: Epigenetic
Novelty: 0.00393172
Score: 0.937
Data Source: STRINGDB
SALL4
Tbio
Family: TF
Novelty: 0.00354374
Score: 0.934
Data Source: STRINGDB
PPARG
Tclin
Family: NR
Novelty: 0.00010033
Score: 0.926
Data Source: STRINGDB
PHC1
Tbio
Novelty: 0.01530622
Score: 0.926
Data Source: STRINGDB
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00065244
Score: 0.924
Data Source: STRINGDB
REST
Tbio
Family: TF
Novelty: 0.00260619
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  74.09

PubMed score by year
PubTator Score  649.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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