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Tchem
ORAI2
Protein orai-2

Protein Summary
Description
Ca(2+) release-activated Ca(2+)-like (CRAC-like) channel subunit which mediates Ca(2+) influx and increase in Ca(2+)-selective current by synergy with the Ca(2+) sensor, STIM1.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356387
  • ENSP00000348752
  • ENSG00000160991
  • ENST00000403646
  • ENSP00000385489
  • ENST00000473939
  • ENSP00000417928
  • ENST00000478730
  • ENSP00000418140
  • ENST00000611770
  • ENSP00000478113

Symbol
  • C7orf19
  • CBCIP2
  • TMEM142B
  • CBCIP2
  • C7orf19
  • MEM142B
  • TMEM142B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.84
histone modification site profile
0.76
tissue sample
0.63
microRNA
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.75   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 32.75   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (2)
1 – 2 of 2
CM4620
chemical structure image
GSK-7975A
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
71.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
71.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ORAI calcium release-activated calcium modulator 2
714917
Mouse
MGI:2443195
269717
Rat
RGD:1310213
304592
Dog
ORAI calcium release-activated calcium modulator 2
VGNC:44138
608106
Horse
ORAI calcium release-activated calcium modulator 2
VGNC:51209
100060645
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ORAI calcium release-activated calcium modulator 2
Mouse
Rat
Dog
ORAI calcium release-activated calcium modulator 2
Horse
ORAI calcium release-activated calcium modulator 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96SN7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Reactome
Cardiac conduction
Reactome
Elevation of cytosolic Ca2+ levels
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Cardiac conduction
Elevation of cytosolic Ca2+ levels
Hemostasis
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (45)
1 – 10 of 45
STIM1
Tbio
Novelty: 0.00116516
Score: 0.996
Data Source: STRINGDB
STIM2
Tbio
Novelty: 0.00446493
Score: 0.993
Data Source: STRINGDB
ITPR3
Tchem
Family: IC
Novelty: 0.00154917
Score: 0.965
Data Source: STRINGDB
ITPR1
Tchem
Family: IC
Novelty: 0.00111834
Score: 0.964
Data Source: STRINGDB
ITPR2
Tbio
Family: IC
Novelty: 0.00619813
Score: 0.949
Data Source: STRINGDB
ORAI1
Tchem
Family: IC
Novelty: 0.00179685
Score: 0.903
Data Source: STRINGDB
ORAI3
Tbio
Novelty: 0.01551802
Score: 0.812
Data Source: STRINGDB
TRPC3
Tchem
Family: IC
Novelty: 0.00268752
Score: 0.797
Data Source: STRINGDB
TRPC1
Tbio
Family: IC
Novelty: 0.00233677
Score: 0.756
Data Source: STRINGDB
CALM3
Tclin
Novelty: 0.00461552
Score: 0.749
Data Source: STRINGDB
Publication Statistics
PubMed Score  32.75

PubMed score by year
PubTator Score  23.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer