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Tbio
HP
Haptoglobin

Protein Summary
Description
As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an antioxidant, has antibacterial activity, and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidly cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. The uncleaved form of allele alpha-2 (2-2), known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens. This gene encodes a preproprotein, which is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. Haptoglobin functions to bind f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355906
  • ENSP00000348170
  • ENSG00000257017
  • ENST00000398131
  • ENSP00000381199
  • ENST00000570083
  • ENSP00000457629

Symbol
  • BP
  • HPA1S
  • HP2ALPHA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
disease
0.81
small molecule perturbation
0.79
cellular component
0.7
tissue
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5876.75   (req: < 5)
Gene RIFs: 263   (req: <= 3)
Antibodies: 1077   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5876.75   (req: >= 5)
Gene RIFs: 263   (req: > 3)
Antibodies: 1077   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
1
1
77.2
low density lipoprotein cholesterol measurement
1
1
1
76.9
high density lipoprotein cholesterol measurement
1
1
1
38.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
total cholesterol measurement
1
77.2
low density lipoprotein cholesterol measurement
1
76.9
high density lipoprotein cholesterol measurement
1
38.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
haptoglobin
706640
Mouse
MGI:96211
15439
Rat
RGD:2825
24464
Dog
haptoglobin-like
479668
Horse
haptoglobin
100067869
Species
Name
OMA
EggNOG
Inparanoid
Macaque
haptoglobin
Mouse
Rat
Dog
haptoglobin-like
Horse
haptoglobin
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00738-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Reactome
Scavenging of heme from plasma
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Immune System
Innate Immune System
Neutrophil degranulation
Scavenging of heme from plasma
Gene Ontology Terms (22)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (272)
1 – 10 of 272
DDX31
Tbio
Family: Enzyme
Novelty: 2.84646195
p_int: 0.999999799
p_ni: 1.98e-7
p_wrong: 3e-9
Data Source: BioPlex
GDPD1
Tbio
Family: Enzyme
Novelty: 0.28722153
p_int: 0.999996156
p_ni: 0.000003834
p_wrong: 1e-8
Score: 0.173
Data Source: BioPlex,STRINGDB
SNX27
Tbio
Novelty: 0.02419724
p_int: 0.999995523
p_ni: 0.000004427
p_wrong: 4.9e-8
Data Source: BioPlex
MAPK6
Tbio
Family: Kinase
Novelty: 0.01012514
p_int: 0.99987588
p_ni: 0.000124115
p_wrong: 4e-9
Score: 0.176
Data Source: BioPlex,STRINGDB
ICE2
Tbio
Novelty: 0.03407933
p_int: 0.998066223
p_ni: 0.001933511
p_wrong: 2.66e-7
Score: 0.204
Data Source: BioPlex,STRINGDB
DDX19B
Tbio
Family: Enzyme
Novelty: 0.0504568
p_int: 0.990286091
p_ni: 0.002744703
p_wrong: 0.006969205
Data Source: BioPlex
HBB
Tbio
Novelty: 0.00049683
Score: 0.993
Data Source: Reactome,STRINGDB
CD163
Tbio
Novelty: 0.0007415
Score: 0.988
Data Source: Reactome,STRINGDB
APOA1
Tbio
Novelty: 0.0001216
Score: 0.979
Data Source: STRINGDB
HBA1
Tclin
Novelty: 0.00094113
Score: 0.977
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  5876.75

PubMed score by year
PubTator Score  3125.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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