Protein Classes
Protein Summary
Transports glucuronic acid and free sialic acid out of the lysosome after it is cleaved from sialoglycoconjugates undergoing degradation, this is required for normal CNS myelination. Mediates aspartate and glutamate membrane potential-dependent uptake into synaptic vesicles and synaptic-like microvesicles. Also functions as an electrogenic 2NO(3)(-)/H(+) cotransporter in the plasma membrane of salivary gland acinar cells, mediating the physiological nitrate efflux, 25% of the circulating nitrate ions is typically removed and secreted in saliva. This gene encodes a membrane transporter that exports free sialic acids that have been cleaved off of cell surface lipids and proteins from lysosomes. Mutations in this gene cause sialic acid storage diseases, including infantile sialic acid storage disorder and and Salla disease, an adult form. [provided by RefSeq, Jul 2008]
- ENST00000355773
- ENSP00000348019
- ENSG00000119899
- SD
- AST
- NSD
- SLD
- ISSD
- SIASD
- SIALIN
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
histone modification site profile | 0.93 | ||
pathway | 0.88 | ||
molecular function | 0.79 | ||
transcription factor binding site profile | 0.77 | ||
kinase perturbation | 0.76 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 911.67 (req: < 5)
Gene RIFs: 20 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 911.67 (req: >= 5)
Gene RIFs: 20 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Pathways (15)
Reactome (14)
KEGG (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 14
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Asparagine N-linked glycosylation | ||||
Reactome | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Reactome | Defective SLC17A5 causes Salla disease (SD) and ISSD | ||||
Reactome | Disease | ||||
Reactome | Disorders of transmembrane transporters | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Asparagine N-linked glycosylation | ||||
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein | ||||
Defective SLC17A5 causes Salla disease (SD) and ISSD | ||||
Disease | ||||
Disorders of transmembrane transporters | ||||
Gene Ontology Terms (17)
Functions (3)
Components (9)
Processes (5)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Protein-Protein Interactions (60)
1 – 10 of 60
LGALS8
Novelty: 0.00746585
p_int: 0.999975167
p_ni: 8.84e-7
p_wrong: 0.000023949
Score: 0.189
Data Source: BioPlex,STRINGDB
TMEM47
Novelty: 0.23378792
p_int: 0.794896293
p_ni: 0.000016936
p_wrong: 0.205086771
Data Source: BioPlex
DDC
Family: Enzyme
Novelty: 0.0016806
Score: 0.813
Data Source: STRINGDB
STMN4
Novelty: 0.00798494
Score: 0.802
Data Source: STRINGDB
MCM4
Novelty: 0.00884931
Score: 0.766
Data Source: STRINGDB
DBF4
Novelty: 0.01069761
Score: 0.757
Data Source: STRINGDB
CDC7
Family: Kinase
Novelty: 0.00526969
Score: 0.719
Data Source: STRINGDB
SLC16A7
Family: Transporter
Novelty: 0.00908316
Score: 0.718
Data Source: STRINGDB
SLC16A3
Family: Transporter
Novelty: 0.00526367
Score: 0.717
Data Source: STRINGDB
STMN1
Novelty: 0.00103914
Score: 0.717
Data Source: STRINGDB
Publication Statistics
PubMed Score 911.67
PubMed score by year
PubTator Score 4205.15
PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDS
1-70
NTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLG
70-140
FGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGT
140-210
VISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSV
210-280
PWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAAD
280-350
NLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPS
350-420
YAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDH
420-490
HGHRH
490-495
MRSPVRDLARNDGEESTDRTPLLPGAPRAEAAPVCCSARYNLAILAFFGFFIVYALRVNLSVALVDMVDSNTTLEDNRTSKACPEHSAPIKVHHNQTGKKYQWDAETQGWILGSFFYGYIITQIPGGYVASKIGGKMLLGFGILGTAVLTLFTPIAADLGVGPLIVLRALEGLGEGVTFPAMHAMWSSWAPPLERSKLLSISYAGAQLGTVISLPLSGIICYYMNWTYVFYFFGTIGIFWFLLWIWLVSDTPQKHKRISHYEKEYILSSLRNQLSSQKSVPWVPILKSLPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFNVQENGFLSSLPYLGSWLCMILSGQAADNLRAKWNFSTLCVRRIFSLIGMIGPAVFLVAAGFIGCDYSLAVAFLTISTTLGGFCSSGFSINHLDIAPSYAGILLGITNTFATIPGMVGPVIAKSLTPDNTVGEWQTVFYIAAAINVFGAIFFTLFAKGEVQNWALNDHHGHRH
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