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Tbio
MYH7
Myosin-7

Protein Summary
Description
Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Muscle myosin is a hexameric protein containing 2 heavy chain subunits, 2 alkali light chain subunits, and 2 regulatory light chain subunits. This gene encodes the beta (or slow) heavy chain subunit of cardiac myosin. It is expressed predominantly in normal human ventricle. It is also expressed in skeletal muscle tissues rich in slow-twitch type I muscle fibers. Changes in the relative abundance of this protein and the alpha (or fast) heavy subunit of cardiac myosin correlate with the contractile velocity of cardiac muscle. Its expression is also altered during thyroid hormone depletion and hemodynamic overloading. Mutations in this gene are associated with familial hypertrophic cardiomyopathy, myosin storage myopathy, dilated cardiomyopat ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
phenotype
0.86
protein domain
0.85
co-expressed gene
0.79
biological term
0.75


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Target Illumination GWAS Analytics (TIGA)
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 348.97   (req: < 5)
Gene RIFs: 134   (req: <= 3)
Antibodies: 285   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 348.97   (req: >= 5)
Gene RIFs: 134   (req: > 3)
Antibodies: 285   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
66.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
66.4
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2155600
140781
Rat
RGD:62030
29557
Dog
myosin heavy chain 7
VGNC:50547
403807
Horse
myosin, heavy chain 7, cardiac muscle, beta
791234
Cow
myosin heavy chain 7
282714
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
myosin heavy chain 7
Horse
myosin, heavy chain 7, cardiac muscle, beta
Cow
myosin heavy chain 7
Protein Structure (21 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12883-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 21
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Dilated cardiomyopathy (DCM)
KEGG
Viral myocarditis
KEGG
Hypertrophic cardiomyopathy (HCM)
KEGG
Cardiac muscle contraction
KEGG
Thyroid hormone signaling pathway
Name
Explore in Pharos
Explore in Source
Dilated cardiomyopathy (DCM)
Viral myocarditis
Hypertrophic cardiomyopathy (HCM)
Cardiac muscle contraction
Thyroid hormone signaling pathway
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
HGNC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (183)
1 – 10 of 183
TLE3
Tbio
Novelty: 0.02641884
p_int: 0.99999999
p_ni: 9e-9
p_wrong: 1e-9
Score: 0.179
Data Source: BioPlex,STRINGDB
RSPH6A
Tdark
Novelty: 0.03734897
p_int: 0.999999977
p_ni: 2.3e-8
Data Source: BioPlex
MECOM
Tbio
Family: TF; Epigenetic
Novelty: 0.00500501
p_int: 0.999999973
p_ni: 2.7e-8
Data Source: BioPlex
LZTR1
Tbio
Novelty: 0.02363333
p_int: 0.999999869
p_ni: 1.31e-7
Data Source: BioPlex
TMEM260
Tdark
Novelty: 0.31409768
p_int: 0.999744732
p_ni: 0.000255266
p_wrong: 2e-9
Score: 0.228
Data Source: BioPlex,STRINGDB
SIX1
Tbio
Family: TF
Novelty: 0.00415613
p_int: 0.99971968
p_ni: 0.000280315
p_wrong: 6e-9
Score: 0.388
Data Source: BioPlex,STRINGDB
AKAP17A
Tbio
Family: Enzyme
Novelty: 0.02860381
p_int: 0.999635665
p_ni: 0.000291924
p_wrong: 0.000072412
Score: 0.167
Data Source: BioPlex,STRINGDB
CDCA8
Tbio
Novelty: 0.01448513
p_int: 0.999295981
p_ni: 0.000703279
p_wrong: 7.4e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
ROGDI
Tbio
Novelty: 0.077277
p_int: 0.998468173
p_ni: 0.001526414
p_wrong: 0.000005413
Score: 0.196
Data Source: BioPlex,STRINGDB
KLHL9
Tdark
Novelty: 0.22434722
p_int: 0.997594986
p_ni: 0.00240063
p_wrong: 0.000004384
Data Source: BioPlex
Publication Statistics
PubMed Score  348.97

PubMed score by year
PubTator Score  276.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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