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Tclin
ANO1
Anoctamin-1

Protein Summary
Description
Calcium-activated chloride channel (CaCC) which plays a role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316296
  • ENSP00000319477
  • ENSG00000131620
  • ENST00000355303
  • ENSP00000347454
  • ENST00000530676
  • ENSP00000435797

Symbol
  • DOG1
  • ORAOV2
  • TAOS2
  • TMEM16A
  • DOG1
  • TAOS2
  • ORAOV2
  • TMEM16A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
gene perturbation
0.87
cellular component
0.8
biological term
0.78
kinase perturbation
0.71


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 779.37   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 1224   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 779.37   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 1224   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 12
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
crofelemer
no chemical structure image available
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
62.6
diastolic blood pressure
1
1
1
56.1
basophil count
2
1
2
45.6
aortic root size
1
1
1
30.1
eosinophil percentage of leukocytes
1
1
1
19.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
62.6
diastolic blood pressure
1
56.1
basophil count
2
45.6
aortic root size
1
30.1
eosinophil percentage of leukocytes
1
19.2
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
anoctamin 1
708723
Mouse
MGI:2142149
101772
Rat
RGD:1310786
309135
Dog
anoctamin 1
VGNC:37923
611698
Horse
anoctamin 1
VGNC:15350
100061836
Species
Name
OMA
EggNOG
Inparanoid
Macaque
anoctamin 1
Mouse
Rat
Dog
anoctamin 1
Horse
anoctamin 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q5XXA6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Ion channel transport (R-HSA-983712)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Ion channel transport
Reactome
Stimuli-sensing channels
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Ion channel transport
Stimuli-sensing channels
Transport of small molecules
Gene Ontology Terms (21)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (130)
1 – 10 of 130
CFTR
Tclin
Family: IC
Novelty: 0.00012639
Score: 0.911
Data Source: STRINGDB
BEST2
Tbio
Family: IC
Novelty: 0.03182837
Score: 0.866
Data Source: STRINGDB
BEST3
Tbio
Family: IC
Novelty: 0.03481733
Score: 0.846
Data Source: STRINGDB
BEST4
Tbio
Family: IC
Novelty: 0.06102944
Score: 0.845
Data Source: STRINGDB
BEST1
Tbio
Family: IC
Novelty: 0.0026324
Score: 0.844
Data Source: STRINGDB
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
Score: 0.799
Data Source: STRINGDB
CLCN2
Tclin
Family: IC
Novelty: 0.00838393
Score: 0.777
Data Source: STRINGDB
CLCNKB
Tchem
Family: IC
Novelty: 0.00982208
Score: 0.772
Data Source: STRINGDB
CLCNKA
Tchem
Family: IC
Novelty: 0.02129502
Score: 0.768
Data Source: STRINGDB
CD34
Tbio
Novelty: 0.00005468
Score: 0.736
Data Source: STRINGDB
Publication Statistics
PubMed Score  779.37

PubMed score by year
PubTator Score  328

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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