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Tbio
SRGAP1
SLIT-ROBO Rho GTPase-activating protein 1

Protein Summary
Description
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42. The protein encoded by this gene is a GTPase activator, working with the GTPase CDC42 to negatively regulate neuronal migration. The encoded protein interacts with the transmembrane receptor ROBO1 to inactivate CDC42. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355086
  • ENSP00000347198
  • ENSG00000196935

Symbol
  • ARHGAP13
  • KIAA1304
  • NMTC2
  • ARHGAP13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.82
transcription factor perturbation
0.8
trait
0.75
cell type or tissue
0.72
microRNA
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.8   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.8   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
56.3
mathematical ability
1
1
1
52
cognitive function measurement
1
1
1
43.8
heel bone mineral density
1
1
1
2.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
56.3
mathematical ability
1
52
cognitive function measurement
1
43.8
heel bone mineral density
1
2.9
Pathways (11)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Inactivation of CDC42 and RAC1
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Inactivation of CDC42 and RAC1
Rho GTPase cycle
Signal Transduction
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (57)
1 – 10 of 57
ROBO1
Tbio
Novelty: 0.00494884
Score: 0.99
Data Source: Reactome,STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.972
Data Source: Reactome,STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.964
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.946
Data Source: STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.946
Data Source: STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.945
Data Source: STRINGDB
SLIT2
Tbio
Novelty: 0.00710401
Score: 0.944
Data Source: Reactome,STRINGDB
RHOU
Tbio
Family: Enzyme
Novelty: 0.01456329
Score: 0.939
Data Source: STRINGDB
RHOD
Tbio
Family: Enzyme
Novelty: 0.0029764
Score: 0.938
Data Source: STRINGDB
RHOG
Tbio
Family: Enzyme
Novelty: 0.00412327
Score: 0.934
Data Source: STRINGDB
Publication Statistics
PubMed Score  13.80

PubMed score by year
PubTator Score  9.76

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer