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Tbio
MYL4
Myosin light chain 4

Protein Summary
Description
Regulatory light chain of myosin. Does not bind calcium. Myosin is a hexameric ATPase cellular motor protein. It is composed of two myosin heavy chains, two nonphosphorylatable myosin alkali light chains, and two phosphorylatable myosin regulatory light chains. This gene encodes a myosin alkali light chain that is found in embryonic muscle and adult atria. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354968
  • ENSP00000347055
  • ENSG00000198336
  • ENST00000393450
  • ENSP00000377096
  • ENST00000572316
  • ENSP00000461570

Symbol
  • MLC1
  • GT1
  • ALC1
  • AMLC
  • PRO1957
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.88
disease perturbation
0.83
PubMedID
0.78
small molecule perturbation
0.69
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.84   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.84   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
1
1
4.8
mean platelet volume
1
1
1
1.6
body mass index
1
1
1
0
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Thyroid preparation use measurement
1
4.8
mean platelet volume
1
1.6
body mass index
1
0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 4
VGNC:9450
454814
Macaque
myosin light chain 4
717354
Mouse
MGI:97267
17896
Rat
RGD:1591197
688228
Dog
myosin light chain 4 [Source:HGNC Symbol;Acc:HGNC:7585]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myosin light chain 4
Macaque
myosin light chain 4
Mouse
Rat
Dog
myosin light chain 4 [Source:HGNC Symbol;Acc:HGNC:7585]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P12829-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Protein-Protein Interactions (116)
1 – 10 of 116
MYH6
Tbio
Novelty: 0.00058671
Score: 0.982
Data Source: Reactome,STRINGDB
MYH3
Tbio
Novelty: 0.00544794
Score: 0.981
Data Source: Reactome,STRINGDB
MYH8
Tbio
Novelty: 0.01020559
Score: 0.981
Data Source: Reactome,STRINGDB
TNNI1
Tbio
Novelty: 0.01639536
Score: 0.972
Data Source: STRINGDB
TNNI3
Tbio
Novelty: 0.00020053
Score: 0.97
Data Source: STRINGDB
TTN
Tbio
Family: Kinase
Novelty: 0.00040356
Score: 0.969
Data Source: Reactome,STRINGDB
TNNT2
Tbio
Novelty: 0.00044568
Score: 0.968
Data Source: STRINGDB
TNNI2
Tbio
Novelty: 0.02772952
Score: 0.966
Data Source: STRINGDB
TNNT1
Tbio
Novelty: 0.00072003
Score: 0.965
Data Source: STRINGDB
MYLK
Tchem
Family: Kinase
Novelty: 0.00102277
Score: 0.964
Data Source: STRINGDB
Publication Statistics
PubMed Score  96.84

PubMed score by year
PubTator Score  32.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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