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Tbio
SCARA5
Scavenger receptor class A member 5

Protein Summary
Description
Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354914
  • ENSP00000346990
  • ENSG00000168079
  • ENST00000380385
  • ENSP00000369746
  • ENST00000518030
  • ENSP00000430713
  • ENST00000524352
  • ENSP00000428663

Symbol
  • Tesr
  • NET33
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.58
biological process
0.56
microRNA
0.53
small molecule perturbation
0.53
disease
0.51


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.77   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 176   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.77   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 176   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
factor VIII measurement
1
2
3
84
von Willebrand factor measurement
1
1
2
78.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
factor VIII measurement
3
84
von Willebrand factor measurement
2
78.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor class A member 5
464079
Macaque
scavenger receptor class A member 5
713377
Mouse
MGI:1918395
71145
Rat
RGD:1306539
305974
Dog
scavenger receptor class A member 5
VGNC:45897
486097
Species
Name
OMA
EggNOG
Inparanoid
Chimp
scavenger receptor class A member 5
Macaque
scavenger receptor class A member 5
Mouse
Rat
Dog
scavenger receptor class A member 5
Pathways (3)
Binding and Uptake of Ligands by Scavenger Receptors (R-HSA-2173782)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Binding and Uptake of Ligands by Scavenger Receptors
Reactome
Scavenging by Class A Receptors
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Binding and Uptake of Ligands by Scavenger Receptors
Scavenging by Class A Receptors
Vesicle-mediated transport
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (35)
1 – 10 of 35
HS3ST2
Tbio
Family: Enzyme
Novelty: 0.0611326
p_int: 0.999990563
p_ni: 0.000009435
p_wrong: 1e-9
Score: 0.297
Data Source: BioPlex,STRINGDB
COLGALT2
Tbio
Family: Enzyme
Novelty: 0.15981994
p_int: 0.908406476
p_ni: 0.09159342
p_wrong: 1.04e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
FTH1
Tbio
Novelty: 0.000863
Score: 0.934
Data Source: Reactome,STRINGDB
FTL
Tbio
Novelty: 0.00235168
Score: 0.929
Data Source: Reactome,STRINGDB
MMACHC
Tbio
Novelty: 0.00896291
Score: 0.664
Data Source: STRINGDB
CNOT11
Tbio
Novelty: 0.01687183
Score: 0.663
Data Source: STRINGDB
TC2N
Tbio
Novelty: 0.16223714
Score: 0.657
Data Source: STRINGDB
MMTAG2
Tdark
Novelty: 0.46434267
Score: 0.651
Data Source: STRINGDB
SOGA3
Tdark
Novelty: 2.17187131
Score: 0.646
Data Source: STRINGDB
ECHDC1
Tbio
Family: Enzyme
Novelty: 0.02711265
Score: 0.605
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.77

PubMed score by year
PubTator Score  21.03

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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