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Tbio
EGFLAM
Pikachurin

Protein Summary
Description
Involved in both the retinal photoreceptor ribbon synapse formation and physiological functions of visual perception. Necessary for proper bipolar dendritic tip apposition to the photoreceptor ribbon synapse. Promotes matrix assembly and cell adhesiveness (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322350
  • ENSP00000313084
  • ENSG00000164318
  • ENST00000336740
  • ENSP00000337607
  • ENST00000354891
  • ENSP00000346964
  • ENST00000397202
  • ENSP00000380385
  • ENST00000397210
  • ENSP00000380393
  • ENST00000506135
  • ENSP00000425579
  • ENST00000514476
  • ENSP00000423228

Symbol
  • AGRINL
  • AGRNL
  • PIKA
  • PIKA
  • AGRNL
  • AGRINL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
gene perturbation
0.85
protein domain
0.85
cell type or tissue
0.77
cell line
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.66   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.66   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
57.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
57.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
EGF like, fibronectin type III and laminin G domains
693314
Mouse
MGI:2146149
268780
Rat
RGD:1306592
365691
Dog
EGF like, fibronectin type III and laminin G domains
VGNC:40239
479359
Horse
EGF like, fibronectin type III and laminin G domains
VGNC:17459
100053309
Species
Name
OMA
EggNOG
Inparanoid
Macaque
EGF like, fibronectin type III and laminin G domains
Mouse
Rat
Dog
EGF like, fibronectin type III and laminin G domains
Horse
EGF like, fibronectin type III and laminin G domains
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q63HQ2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (49)
1 – 10 of 49
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.99999998
p_ni: 1.4e-8
p_wrong: 6e-9
Score: 0.177
Data Source: BioPlex,STRINGDB
FGF1
Tchem
Novelty: 0.00055979
p_int: 0.998554615
p_ni: 0.000002514
p_wrong: 0.001442871
Score: 0.656
Data Source: BioPlex,STRINGDB
HADHA
Tbio
Novelty: 0.00385746
p_int: 0.997563568
p_ni: 0.000095399
p_wrong: 0.002341033
Data Source: BioPlex
DAG1
Tbio
Family: Enzyme
Novelty: 0.00149278
Score: 0.877
Data Source: STRINGDB
STAB2
Tbio
Novelty: 0.01141869
Score: 0.802
Data Source: STRINGDB
POMT2
Tbio
Family: Enzyme
Novelty: 0.0251595
Score: 0.711
Data Source: STRINGDB
DMD
Tclin
Novelty: 0.00025661
Score: 0.635
Data Source: STRINGDB
LYZL6
Tbio
Family: Enzyme
Novelty: 0.09937272
Score: 0.631
Data Source: STRINGDB
LYZL4
Tbio
Family: Enzyme
Novelty: 0.14684776
Score: 0.628
Data Source: STRINGDB
POMT1
Tbio
Family: Enzyme
Novelty: 0.01971429
Score: 0.619
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.66

PubMed score by year
PubTator Score  13.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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