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Tbio
CRYBA4
Beta-crystallin A4

Protein Summary
Description
Crystallins are the dominant structural components of the vertebrate eye lens. Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families; beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Beta-crystallins, the most heterogeneous, differ by the presence of the C-terminal extension (present in the basic group, none in the acidic group). Beta-crystallins form aggregates of dif ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354760
  • ENSP00000346805
  • ENSG00000196431

Symbol
  • CYRBA4
  • CTRCT23
  • MCOPCT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.81
co-expressed gene
0.65
kinase perturbation
0.54
cell line
0.49
disease perturbation
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.48   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.48   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
crystallin beta A4
VGNC:5247
470171
Macaque
crystallin beta A4
715477
Mouse
MGI:102716
12959
Rat
RGD:61962
64348
Dog
crystallin beta A4
VGNC:39638
486334
Species
Name
OMA
EggNOG
Inparanoid
Chimp
crystallin beta A4
Macaque
crystallin beta A4
Mouse
Rat
Dog
crystallin beta A4
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P53673-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
HSF1 activation
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
HSF1 activation
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (48)
1 – 10 of 48
EML5
Tdark
Novelty: 0.29826509
p_int: 0.999994207
p_ni: 0.000005793
Score: 0.218
Data Source: BioPlex,STRINGDB
DDB2
Tbio
Novelty: 0.00648809
p_int: 0.999962454
p_ni: 0.000037546
Score: 0.547
Data Source: BioPlex,STRINGDB
RBP4
Tchem
Novelty: 0.00168442
p_int: 0.999599501
p_ni: 0.000398796
p_wrong: 0.000001703
Score: 0.161
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.991141817
p_ni: 0.008858183
Data Source: BioPlex
CUL4B
Tbio
Novelty: 0.0133075
p_int: 0.975423513
p_ni: 0.024576487
Data Source: BioPlex
TJP1
Tbio
Novelty: 0.00040365
p_int: 0.949196867
p_ni: 0.050803131
p_wrong: 1e-9
Score: 0.167
Data Source: BioPlex,STRINGDB
FOXF2
Tbio
Family: TF
Novelty: 0.02032168
p_int: 0.942621915
p_ni: 0.004818874
p_wrong: 0.052559211
Score: 0.173
Data Source: BioPlex,STRINGDB
APAF1
Tbio
Family: Enzyme
Novelty: 0.00107622
p_int: 0.934035888
p_ni: 0.064605341
p_wrong: 0.001358771
Score: 0.167
Data Source: BioPlex,STRINGDB
RICTOR
Tbio
Novelty: 0.00250734
p_int: 0.886673882
p_ni: 0.11332502
p_wrong: 0.000001098
Data Source: BioPlex
DISC1
Tbio
Novelty: 0.00183442
p_int: 0.860143355
p_ni: 0.090283153
p_wrong: 0.049573492
Score: 0.183
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  24.48

PubMed score by year
PubTator Score  15.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer