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Tbio
ELOVL2
Elongation of very long chain fatty acids protein 2

Protein Summary
Description
Catalyzes the first and rate-limiting reaction of the four that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate in the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354666
  • ENSP00000346693
  • ENSG00000197977

Symbol
  • SSC2
  • SSC2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
PubMedID
0.63
microRNA
0.62
histone modification site profile
0.6
tissue sample
0.56


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.93   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.93   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
docosapentaenoic acid measurement
2
2
2
93.9
docosahexaenoic acid measurement
1
1
1
78.3
blood metabolite measurement
1
1
2
74.7
glycerophospholipid measurement
1
1
2
74.7
metabolite measurement
1
1
1
74
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
docosapentaenoic acid measurement
2
93.9
docosahexaenoic acid measurement
1
78.3
blood metabolite measurement
2
74.7
glycerophospholipid measurement
2
74.7
metabolite measurement
1
74
Pathways (25)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Linoleic acid (LA) metabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Linoleic acid (LA) metabolism
Metabolism
Metabolism of lipids
Gene Ontology Terms (17)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (80)
1 – 10 of 80
SLC22A9
Tbio
Family: Transporter
Novelty: 0.02212992
p_int: 0.99998992
p_ni: 0.000009896
p_wrong: 1.84e-7
Data Source: BioPlex
TRIM13
Tbio
Family: Enzyme
Novelty: 0.00085649
p_int: 0.999958507
p_ni: 0.000041397
p_wrong: 9.6e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
VIPR2
Tchem
Family: GPCR
Novelty: 0.00463802
p_int: 0.999372066
p_ni: 0.000627931
p_wrong: 3e-9
Data Source: BioPlex
C3AR1
Tchem
Family: GPCR
Novelty: 0.00527301
p_int: 0.998802469
p_ni: 0.00119165
p_wrong: 0.000005882
Data Source: BioPlex
SLC39A4
Tbio
Family: Transporter
Novelty: 0.00742159
p_int: 0.998731962
p_ni: 0.001214683
p_wrong: 0.000053355
Score: 0.165
Data Source: BioPlex,STRINGDB
FPR2
Tchem
Family: GPCR
Novelty: 0.00228744
p_int: 0.998617442
p_ni: 0.001323078
p_wrong: 0.00005948
Data Source: BioPlex
LPAR1
Tchem
Family: GPCR
Novelty: 0.00318056
p_int: 0.98329885
p_ni: 0.016690007
p_wrong: 0.000011143
Score: 0.161
Data Source: BioPlex,STRINGDB
GPR21
Tdark
Family: GPCR
Novelty: 0.90865557
p_int: 0.965316743
p_ni: 0.033893573
p_wrong: 0.000789684
Data Source: BioPlex
HSD17B12
Tbio
Family: Enzyme
Novelty: 0.02200219
Score: 0.949
Data Source: STRINGDB
FADS2
Tbio
Family: Enzyme
Novelty: 0.00180901
Score: 0.837
Data Source: STRINGDB
Publication Statistics
PubMed Score  147.93

PubMed score by year
PubTator Score  44.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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