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Tbio
SMOC2
SPARC-related modular calcium-binding protein 2

Protein Summary
Description
Promotes matrix assembly and cell adhesiveness (By similarity). Can stimulate endothelial cell proliferation, migration, as well as angiogenesis. This gene encodes a member of the SPARC family (secreted protein acidic and rich in cysteine/osteonectin/BM-40), which are highly expressed during embryogenesis and wound healing. The gene product is a matricellular protein which promotes matrix assembly and can stimulate endothelial cell proliferation and migration, as well as angiogenic activity. Associated with pulmonary function, this secretory gene product contains a Kazal domain, two thymoglobulin type-1 domains, and two EF-hand calcium-binding domains. The encoded protein may serve as a target for controlling angiogenesis in tumor growth and myocardial ischemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354536
  • ENSP00000346537
  • ENSG00000112562
  • ENST00000356284
  • ENSP00000348630

Symbol
  • SMAP2
  • DTDP1
  • SMAP2
  • MST117
  • MSTP117
  • MSTP140
  • bA37D8.1
  • bA270C4A.1
  • dJ421D16.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
PubMedID
0.77
trait
0.75
tissue sample
0.62
disease
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.96   (req: < 5)
Gene RIFs: 17   (req: <= 3)
Antibodies: 131   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 37.96   (req: >= 5)
Gene RIFs: 17   (req: > 3)
Antibodies: 131   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pulse pressure measurement
1
25.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPARC related modular calcium binding 2
VGNC:3704
463137
Mouse
MGI:1929881
64074
Rat
RGD:1306681
292401
Dog
SPARC related modular calcium binding 2
VGNC:46567
476270
Horse
SPARC related modular calcium binding 2
VGNC:23351
100054389
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPARC related modular calcium binding 2
Mouse
Rat
Dog
SPARC related modular calcium binding 2
Horse
SPARC related modular calcium binding 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9H3U7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (44)
1 – 10 of 44
SPOCK3
Tbio
Novelty: 0.11871451
Score: 0.679
Data Source: STRINGDB
DACT2
Tbio
Novelty: 0.05348682
Score: 0.658
Data Source: STRINGDB
TES
Tbio
Novelty: 0.00052221
Score: 0.644
Data Source: STRINGDB
FRMD1
Tdark
Novelty: 0.96833141
Score: 0.617
Data Source: STRINGDB
PHF10
Tbio
Family: Epigenetic
Novelty: 0.05941323
Score: 0.615
Data Source: STRINGDB
TCTE3
Tdark
Novelty: 0.15747856
Score: 0.599
Data Source: STRINGDB
SPARCL1
Tbio
Novelty: 0.01077806
Score: 0.595
Data Source: STRINGDB
STS
Tchem
Family: Enzyme
Novelty: 0.00324549
Score: 0.568
Data Source: STRINGDB
OLFM4
Tbio
Novelty: 0.01048505
Score: 0.558
Data Source: STRINGDB
LGR5
Tbio
Family: GPCR
Novelty: 0.00105035
Score: 0.547
Data Source: STRINGDB
Publication Statistics
PubMed Score  37.96

PubMed score by year
PubTator Score  20.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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