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Tclin
SCN8A
Sodium channel protein type 8 subunit alpha

Protein Classes
Protein Summary
Description
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation. This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354534
  • ENSP00000346534
  • ENSG00000196876
  • ENST00000355133
  • ENSP00000347255
  • ENST00000545061
  • ENSP00000440360
  • ENST00000599343
  • ENSP00000476447
  • ENST00000627620
  • ENSP00000487583

Symbol
  • MED
  • MED
  • PN4
  • CIAT
  • BFIS5
  • NaCh6
  • CERIII
  • EIEE13
  • MYOCL2
  • Nav1.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
protein domain
0.92
cellular component
0.76
histone modification site profile
0.75
transcription factor
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.1   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 197   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 506.1   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 197   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
1
51
alcohol consumption measurement
1
1
1
37.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
51
alcohol consumption measurement
1
37.4
Pathways (8)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cardiac conduction
Reactome
Developmental Biology
Reactome
Interaction between L1 and Ankyrins
Reactome
L1CAM interactions
Name
Explore in Pharos
Explore in Source
Axon guidance
Cardiac conduction
Developmental Biology
Interaction between L1 and Ankyrins
L1CAM interactions
Protein-Protein Interactions (121)
1 – 10 of 121
ANK3
Tbio
Novelty: 0.00429246
Score: 0.981
Data Source: STRINGDB
SCN1B
Tbio
Family: IC
Novelty: 0.00910273
Score: 0.976
Data Source: STRINGDB
NFASC
Tbio
Novelty: 0.00545331
Score: 0.972
Data Source: STRINGDB
SCN4B
Tbio
Family: IC
Novelty: 0.02505113
Score: 0.966
Data Source: STRINGDB
SCN3B
Tbio
Family: IC
Novelty: 0.0438123
Score: 0.96
Data Source: STRINGDB
SCN2B
Tbio
Family: IC
Novelty: 0.03773629
Score: 0.96
Data Source: STRINGDB
NRCAM
Tbio
Novelty: 0.00443497
Score: 0.957
Data Source: STRINGDB
ANK2
Tbio
Novelty: 0.00528351
Score: 0.956
Data Source: STRINGDB
SPTBN4
Tbio
Novelty: 0.02182293
Score: 0.954
Data Source: STRINGDB
SPTAN1
Tbio
Novelty: 0.00286901
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  506.10

PubMed score by year
PubTator Score  131.47

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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