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Tchem
PDGFA
Platelet-derived growth factor subunit A

Protein Summary
Description
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB (By similarity). This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000354513
  • ENSP00000346508
  • ENSG00000197461
  • ENST00000402802
  • ENSP00000383889

Symbol
  • PDGF1
  • PDGF1
  • PDGF-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
PubMedID
1
kinase perturbation
0.91
transcription factor perturbation
0.91
small molecule perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 542.11   (req: < 5)
Gene RIFs: 108   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 542.11   (req: >= 5)
Gene RIFs: 108   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL3125890
chemical structure image
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (97)
Constitutive Signaling by Aberrant PI3K in Cancer (R-HSA-2219530)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 26
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downstream signal transduction
Name
Explore in Pharos
Explore in Source
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Downstream signal transduction
Gene Ontology Terms (52)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (149)
1 – 10 of 149
PDGFRA
Tclin
Family: Kinase
Novelty: 0.00103644
Score: 0.988
Data Source: Reactome,STRINGDB
PDGFRB
Tclin
Family: Kinase
Novelty: 0.00115144
Score: 0.984
Data Source: Reactome,STRINGDB
PDGFC
Tbio
Novelty: 0.00874564
Score: 0.968
Data Source: STRINGDB
PDGFD
Tbio
Novelty: 0.00955028
Score: 0.961
Data Source: STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00125418
Score: 0.948
Data Source: Reactome,STRINGDB
HSPG2
Tbio
Family: Enzyme
Novelty: 0.0008386
Score: 0.947
Data Source: STRINGDB
PDGFB
Tchem
Novelty: 0.000542
Score: 0.936
Data Source: Reactome,STRINGDB
PIK3CA
Tclin
Family: Kinase
Novelty: 0.00077082
Score: 0.929
Data Source: Reactome,STRINGDB
PIK3R1
Tchem
Family: Kinase
Novelty: 0.00286014
Score: 0.921
Data Source: Reactome,STRINGDB
SHC1
Tchem
Novelty: 0.00113167
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  542.11

PubMed score by year
PubTator Score  366.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLDTSLRAHGVHA
1-70
TKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKC
70-140
QPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTGRPRESGKKRKRKRLKP
140-210
T
210-211
MRTLACLLLLGCGYLAHVLAEEAEIPREVIERLARSQIHSIRDLQRLLEIDSVGSEDSLDTSLRAHGVHATKHVPEKRPLPIRRKRSIEEAVPAVCKTRTVIYEIPRSQVDPTSANFLIWPPCVEVKRCTGCCNTSSVKCQPSRVHHRSVKVAKVEYVRKKPKLKEVQVRLEEHLECACATTSLNPDYREEDTGRPRESGKKRKRKRLKPT