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Tbio
KIAA0586
Protein TALPID3

Protein Summary
Description
Required for ciliogenesis and sonic hedgehog/SHH signaling. Required for the centrosomal recruitment of RAB8A and for the targeting of centriole satellite proteins to centrosomes such as of PCM1. May play a role in early ciliogenesis in the disappearance of centriolar satellites that preceeds ciliary vesicle formation (PubMed:24421332). Involved in regulation of cell intracellular organization. Involved in regulation of cell polarity (By similarity). Required for asymmetrical localization of CEP120 to daughter centrioles (By similarity). This gene encodes a conserved centrosomal protein that functions in ciliogenesis and responds to hedgehog signaling. Mutations in this gene causes Joubert syndrome 23. Alternative splicing results in multiple transcript variants and protein isoforms. [provided by RefSeq, Aug 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261244
  • ENSP00000261244
  • ENSG00000100578
  • ENST00000354386
  • ENSP00000346359
  • ENST00000423743
  • ENSP00000399427
  • ENST00000556134
  • ENSP00000452351
  • ENST00000619416
  • ENSP00000478083

Symbol
  • TALPID3
  • JBTS23
  • SRTD14
  • Talpid3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.88
virus perturbation
0.88
co-expressed gene
0.79
transcription factor
0.73
cell line
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.79   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 10   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.79   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 10   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
KIAA0586
VGNC:3400
452937
Macaque
KIAA0586 ortholog
702803
Mouse
MGI:1924217
76967
Rat
RGD:1585176
690035
Dog
KIAA0586
VGNC:42349
480340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
KIAA0586
Macaque
KIAA0586 ortholog
Mouse
Rat
Dog
KIAA0586
Pathways (11)
Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Joubert Syndrome
WikiPathways
Joubert Syndrome
WikiPathways
Joubert Syndrome
WikiPathways
Joubert Syndrome
WikiPathways
Joubert Syndrome
Name
Explore in Pharos
Explore in Source
Joubert Syndrome
Joubert Syndrome
Joubert Syndrome
Joubert Syndrome
Joubert Syndrome
Gene Ontology Terms (7)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (61)
1 – 10 of 61
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.999997849
p_ni: 0.000002145
p_wrong: 5e-9
Data Source: BioPlex
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.999984927
p_ni: 0.000015049
p_wrong: 2.4e-8
Data Source: BioPlex
NCAPH2
Tbio
Novelty: 0.12134933
p_int: 0.99998089
p_ni: 0.0000191
p_wrong: 1e-8
Data Source: BioPlex
IL17RA
Tclin
Novelty: 0.00416706
p_int: 0.99988138
p_ni: 0.000089736
p_wrong: 0.000028885
Data Source: BioPlex
CEP120
Tbio
Novelty: 0.07215656
Score: 0.771
Data Source: STRINGDB
CCP110
Tbio
Novelty: 0.02399511
Score: 0.744
Data Source: STRINGDB
PIFO
Tbio
Novelty: 0.23031682
Score: 0.663
Data Source: STRINGDB
KIF24
Tbio
Novelty: 0.13497665
Score: 0.65
Data Source: STRINGDB
CNTLN
Tbio
Novelty: 0.0044959
Score: 0.64
Data Source: STRINGDB
C2CD3
Tbio
Novelty: 0.10910688
Score: 0.623
Data Source: STRINGDB
Publication Statistics
PubMed Score  33.79

PubMed score by year
PubTator Score  9.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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