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Tbio
GJB4
Gap junction beta-4 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene encodes a transmembrane connexin protein that is a component of gap junctions. Mutations in this gene have been associated with erythrokeratodermia variabilis, progressive symmetric erythrokeratoderma and hearing impairment. [provided by RefSeq, Dec 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339480
  • ENSP00000345868
  • ENSG00000189433

Symbol
  • EKV
  • EKVP2
  • CX30.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
PubMedID
0.6
gene perturbation
0.5
transcription factor
0.49
microRNA
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.63   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 164   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.63   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 164   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
Gap junction assembly (R-HSA-190861)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gap junction assembly
Reactome
Gap junction trafficking
Reactome
Gap junction trafficking and regulation
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Gap junction assembly
Gap junction trafficking
Gap junction trafficking and regulation
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (8)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (24)
1 – 10 of 24
PSME1
Tbio
Novelty: 0.01258149
p_int: 0.757451701
p_ni: 0.242548299
Score: 0.252
Data Source: BioPlex,STRINGDB
RPL34
Tbio
Novelty: 0.02236592
Score: 0.809
Data Source: STRINGDB
GJE1
Tdark
Novelty: 0.03519662
Score: 0.652
Data Source: STRINGDB
CLEC2A
Tbio
Novelty: 0.14656329
Score: 0.643
Data Source: STRINGDB
GJB5
Tbio
Novelty: 0.04928204
Score: 0.64
Data Source: STRINGDB
GJB3
Tbio
Novelty: 0.00612314
Score: 0.593
Data Source: STRINGDB
GJC3
Tbio
Novelty: 0.02619721
Score: 0.454
Data Source: STRINGDB
PANX1
Tbio
Family: IC
Novelty: 0.00159814
Score: 0.453
Data Source: STRINGDB
GJC1
Tbio
Novelty: 0.00375192
Score: 0.435
Data Source: STRINGDB
GJD2
Tbio
Novelty: 0.00263903
Score: 0.423
Data Source: STRINGDB
Publication Statistics
PubMed Score  42.63

PubMed score by year
PubTator Score  22.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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