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Tbio
GATA2
Endothelial transcription factor GATA-2

Protein Summary
Description
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'. This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341105
  • ENSP00000345681
  • ENSG00000179348
  • ENST00000430265
  • ENSP00000400259
  • ENST00000487848
  • ENSP00000417074

Symbol
  • DCML
  • IMD21
  • NFE1B
  • MONOMAC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor perturbation
0.98
molecular function
0.96
PubMedID
0.96
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.4   (req: < 5)
Gene RIFs: 150   (req: <= 3)
Antibodies: 446   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 638.4   (req: >= 5)
Gene RIFs: 150   (req: > 3)
Antibodies: 446   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
2
2
78.6
neutrophil percentage of leukocytes
1
1
1
53.4
neutrophil count
1
1
1
39.6
monocyte count
1
1
1
37.4
platelet crit
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
78.6
neutrophil percentage of leukocytes
1
53.4
neutrophil count
1
39.6
monocyte count
1
37.4
platelet crit
1
30.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GATA binding protein 2
VGNC:1824
460672
Macaque
GATA binding protein 2
705551
Mouse
MGI:95662
14461
Rat
RGD:2664
25159
Dog
GATA binding protein 2
VGNC:41122
484626
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GATA binding protein 2
Macaque
GATA binding protein 2
Mouse
Rat
Dog
GATA binding protein 2
Pathways (21)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Developmental Biology
Factors involved in megakaryocyte development and platelet production
Gene expression (Transcription)
Generic Transcription Pathway
Hemostasis
Gene Ontology Terms (61)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (269)
1 – 10 of 269
ZFPM1
Tbio
Family: TF
Novelty: 0.01061715
p_int: 0.999998747
p_ni: 0.000001025
p_wrong: 2.27e-7
Score: 0.986
Data Source: BioPlex,STRINGDB
TRAPPC9
Tbio
Novelty: 0.02703008
p_int: 0.999883032
p_ni: 0.000116968
Score: 0.209
Data Source: BioPlex,STRINGDB
TRAPPC10
Tbio
Novelty: 0.03433058
p_int: 0.999456585
p_ni: 0.000543415
Score: 0.189
Data Source: BioPlex,STRINGDB
TRAPPC4
Tbio
Novelty: 0.05749912
p_int: 0.946076749
p_ni: 0.053923251
Score: 0.189
Data Source: BioPlex,STRINGDB
IMPDH1
Tclin
Family: Enzyme
Novelty: 0.00758575
p_int: 0.850198377
p_ni: 0.149801623
Score: 0.216
Data Source: BioPlex,STRINGDB
LMO2
Tbio
Novelty: 0.0038279
Score: 0.99
Data Source: STRINGDB
TAL1
Tbio
Family: TF
Novelty: 0.00294416
Score: 0.99
Data Source: STRINGDB
LDB1
Tbio
Novelty: 0.01110112
Score: 0.974
Data Source: STRINGDB
RUNX1
Tbio
Family: TF
Novelty: 0.0085181
Score: 0.968
Data Source: STRINGDB
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.967
Data Source: STRINGDB
Publication Statistics
PubMed Score  638.40

PubMed score by year
PubTator Score  397.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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