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Tbio
E2F1
Transcription factor E2F1

Protein Summary
Description
Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812). Positively regulates transcription of RRP1B (PubMed:20040599). The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally co ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343380
  • ENSP00000345571
  • ENSG00000101412

Symbol
  • RBBP3
  • RBP3
  • E2F-1
  • RBAP1
  • RBBP3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
hub protein
0.99
kinase
0.98
virus
0.98
pathway
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.66   (req: < 5)
Gene RIFs: 536   (req: <= 3)
Antibodies: 1343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 340.66   (req: >= 5)
Gene RIFs: 536   (req: > 3)
Antibodies: 1343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
86
body height
1
1
1
36
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
86
body height
1
36
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (105)
Activation of BH3-only proteins (R-HSA-114452)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 45
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BH3-only proteins
Reactome
Activation of NOXA and translocation to mitochondria
Reactome
Activation of PUMA and translocation to mitochondria
Reactome
Apoptosis
Reactome
Assembly of the pre-replicative complex
Name
Explore in Pharos
Explore in Source
Activation of BH3-only proteins
Activation of NOXA and translocation to mitochondria
Activation of PUMA and translocation to mitochondria
Apoptosis
Assembly of the pre-replicative complex
Gene Ontology Terms (51)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred by Curator (IC)
NTNU_SB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (287)
1 – 10 of 287
TFDP2
Tbio
Family: TF
Novelty: 0.14331363
p_int: 0.999998964
p_wrong: 0.000001036
Score: 0.925
Data Source: BioPlex,Reactome,STRINGDB
RB1
Tchem
Novelty: 0.00063798
Score: 0.999
Data Source: Reactome,STRINGDB
TFDP1
Tbio
Family: TF
Novelty: 0.02026858
Score: 0.996
Data Source: Reactome,STRINGDB
CDC6
Tbio
Novelty: 0.00219371
Score: 0.991
Data Source: STRINGDB
RBL1
Tbio
Novelty: 0.00228265
Score: 0.991
Data Source: STRINGDB
CCNA2
Tchem
Novelty: 0.00049887
Score: 0.989
Data Source: STRINGDB
CDKN2A
Tbio
Novelty: 0.00014147
Score: 0.987
Data Source: STRINGDB
CDKN2A
Tbio
Family: Enzyme
Novelty: 0.00014147
Score: 0.987
Data Source: STRINGDB
CDK2
Tchem
Family: Kinase
Novelty: 0.00032118
Score: 0.985
Data Source: Reactome,STRINGDB
RBL2
Tbio
Novelty: 0.00121893
Score: 0.981
Data Source: STRINGDB
Publication Statistics
PubMed Score  340.66

PubMed score by year
PubTator Score  1160.35

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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