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Tbio
SH2B3
SH2B adapter protein 3

Protein Summary
Description
Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac disease type 13 and susceptibility to insulin-dependent diabetes mellitus. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341259
  • ENSP00000345492
  • ENSG00000111252

Symbol
  • LNK
  • LNK
  • IDDM20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
transcription factor binding site profile
0.93
kinase perturbation
0.88
disease perturbation
0.87
transcription factor
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.55   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 231   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.55   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 231   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (59)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
3
3
5.3
97.6
eosinophil count
2
1
1
7.6
95.6
lymphocyte count
3
2
3
91.9
monocyte count
3
2
3
91.3
high density lipoprotein cholesterol measurement
2
1
3
89.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
3
5.3
97.6
eosinophil count
1
7.6
95.6
lymphocyte count
3
91.9
monocyte count
3
91.3
high density lipoprotein cholesterol measurement
3
89.8
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SH2B adaptor protein 3
VGNC:5581
452245
Macaque
SH2B adaptor protein 3
710839
Mouse
MGI:893598
16923
Dog
SH2B adaptor protein 3
VGNC:46110
100683018
Cow
SH2B adaptor protein 3
VGNC:34556
614726
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SH2B adaptor protein 3
Macaque
SH2B adaptor protein 3
Mouse
Dog
SH2B adaptor protein 3
Cow
SH2B adaptor protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UQQ2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Factors involved in megakaryocyte development and platelet production (R-HSA-983231)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Regulation of KIT signaling
Reactome
Signal Transduction
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Factors involved in megakaryocyte development and platelet production
Hemostasis
Regulation of KIT signaling
Signal Transduction
Signaling by Receptor Tyrosine Kinases
Protein-Protein Interactions (94)
1 – 10 of 94
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.979
Data Source: Reactome,STRINGDB
KIT
Tclin
Family: Kinase
Novelty: 0.00011237
Score: 0.96
Data Source: Reactome,STRINGDB
EPOR
Tclin
Novelty: 0.00134388
Score: 0.953
Data Source: STRINGDB
GRB2
Tchem
Novelty: 0.00091605
Score: 0.944
Data Source: STRINGDB
EPO
Tbio
Novelty: 0.00013701
Score: 0.94
Data Source: STRINGDB
KITLG
Tbio
Novelty: 0.00036337
Score: 0.93
Data Source: Reactome,STRINGDB
SOCS3
Tbio
Novelty: 0.00106095
Score: 0.927
Data Source: STRINGDB
LCK
Tclin
Family: Kinase
Novelty: 0.00058377
Score: 0.905
Data Source: STRINGDB
SH2B1
Tbio
Novelty: 0.01659457
Score: 0.866
Data Source: STRINGDB
NTRK1
Tclin
Family: Kinase
Novelty: 0.00033453
Score: 0.859
Data Source: STRINGDB
Publication Statistics
PubMed Score  230.55

PubMed score by year
PubTator Score  147.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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