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Tbio
UBQLN2
Ubiquilin-2

Protein Summary
Description
Plays an important role in the regulation of different protein degradation mechanisms and pathways including ubiquitin-proteasome system (UPS), autophagy and the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (PubMed:10983987). Plays a role in the ERAD pathway via its interaction with ER-localized proteins FAF2/UBXD8 and HERPUD1 and may form a link between the polyubiquitinated ERAD substrates and the proteasome (PubMed:24215460, PubMed:18307982). Involved in the regulation of macroautophagy and autophagosome formation; required for maturation of autophagy-related protein LC3 from the cytosolic form LC3-I to the membrane-bound form LC3-II and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosom ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338222
  • ENSP00000345195
  • ENSG00000188021

Symbol
  • N4BP4
  • PLIC2
  • DSK2
  • ALS15
  • CHAP1
  • N4BP4
  • PLIC2
  • HRIHFB2157
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.98
transcription factor perturbation
0.91
kinase perturbation
0.84
disease perturbation
0.68


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.49   (req: < 5)
Gene RIFs: 49   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.49   (req: >= 5)
Gene RIFs: 49   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (5)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Gene Ontology Terms (13)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (323)
1 – 10 of 323
TMEM31
Tdark
Novelty: 0.65381391
p_int: 0.986737183
p_ni: 0.013262817
Data Source: BioPlex
SLC17A2
Tdark
Family: Transporter
Novelty: 0.23941275
p_int: 0.808123376
p_ni: 0.191876622
p_wrong: 2e-9
Score: 0.235
Data Source: BioPlex,STRINGDB
STAM
Tbio
Novelty: 0.0332731
Score: 0.985
Data Source: STRINGDB
UBA52
Tbio
Novelty: 0.01637744
Score: 0.978
Data Source: STRINGDB
UBC
Tbio
Novelty: 0.00204643
Score: 0.965
Data Source: STRINGDB
EPS15
Tbio
Novelty: 0.00451447
Score: 0.954
Data Source: Reactome,STRINGDB
UBL7
Tdark
Novelty: 0.20935024
Score: 0.952
Data Source: STRINGDB
RPS27A
Tbio
Novelty: 0.00658124
Score: 0.947
Data Source: STRINGDB
PSMD4
Tbio
Family: Enzyme
Novelty: 0.00614538
Score: 0.945
Data Source: STRINGDB
UBB
Tbio
Novelty: 0.00661254
Score: 0.945
Data Source: STRINGDB
Publication Statistics
PubMed Score  131.49

PubMed score by year
PubTator Score  65.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer