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Tclin
IMPDH1
Inosine-5'-monophosphate dehydrogenase 1

Protein Summary
Description
Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338791
  • ENSP00000345096
  • ENSG00000106348
  • ENST00000348127
  • ENSP00000265385
  • ENST00000354269
  • ENSP00000346219
  • ENST00000419067
  • ENSP00000399400
  • ENST00000480861
  • ENSP00000420185
  • ENST00000496200
  • ENSP00000420803

Symbol
  • IMPD1
  • IMPD
  • RP10
  • IMPD1
  • LCA11
  • IMPDH-I
  • sWSS2608
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.84
kinase perturbation
0.76
disease perturbation
0.74
protein domain
0.73
co-expressed gene
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.38   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 251   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.38   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 251   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 94
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pelvic organ prolapse
1
1
0
1.3
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
pelvic organ prolapse
0
1.3
66.8
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism
Metabolism of nucleotides
Neutrophil degranulation
Gene Ontology Terms (18)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (293)
1 – 10 of 293
IMPDH2
Tclin
Family: Enzyme
Novelty: 0.00815361
p_int: 0.999999974
p_ni: 2.6e-8
Score: 0.971
Data Source: BioPlex,STRINGDB
SMCR8
Tbio
Novelty: 0.11500348
p_int: 0.999998675
p_ni: 0.000001325
Score: 0.483
Data Source: BioPlex,STRINGDB
WDR25
Tdark
Novelty: 0.53632123
p_int: 0.999998481
p_ni: 5.86e-7
p_wrong: 9.34e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
SDHC
Tbio
Family: Enzyme
Novelty: 0.0005776
p_int: 0.999996898
p_ni: 4.4e-8
p_wrong: 0.000003058
Score: 0.24
Data Source: BioPlex,STRINGDB
ARHGEF39
Tdark
Novelty: 0.30447134
p_int: 0.999991914
p_ni: 0.000006993
p_wrong: 0.000001093
Score: 0.173
Data Source: BioPlex,STRINGDB
ANKRD9
Tdark
Novelty: 0.43181793
p_int: 0.999991106
p_ni: 0.000002868
p_wrong: 0.000006026
Score: 0.804
Data Source: BioPlex,STRINGDB
TRIM6
Tbio
Novelty: 0.13070728
p_int: 0.999988223
p_ni: 0.000011772
p_wrong: 6e-9
Score: 0.225
Data Source: BioPlex,STRINGDB
SLC25A44
Tdark
Family: Transporter
Novelty: 0.36924538
p_int: 0.99998199
p_ni: 2.93e-7
p_wrong: 0.000017717
Score: 0.525
Data Source: BioPlex,STRINGDB
MRM2
Tbio
Family: Enzyme
Novelty: 0.06394065
p_int: 0.999961234
p_ni: 0.000037276
p_wrong: 0.00000149
Score: 0.281
Data Source: BioPlex,STRINGDB
B3GNTL1
Tdark
Family: Enzyme
Novelty: 0.13396783
p_int: 0.999955462
p_ni: 1.84e-7
p_wrong: 0.000044354
Score: 0.242
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  131.38

PubMed score by year
PubTator Score  90.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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