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Tbio
NFASC
Neurofascin

Protein Summary
Description
Cell adhesion, ankyrin-binding protein which may be involved in neurite extension, axonal guidance, synaptogenesis, myelination and neuron-glial cell interactions. This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.[provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339876
  • ENSP00000344786
  • ENSG00000163531
  • ENST00000360049
  • ENSP00000353154
  • ENST00000401399
  • ENSP00000385637
  • ENST00000403080
  • ENSP00000384875
  • ENST00000404076
  • ENSP00000385676
  • ENST00000404907
  • ENSP00000384061
  • ENST00000513543
  • ENSP00000425908
  • ENST00000539706
  • ENSP00000438614

Symbol
  • KIAA0756
  • NF
  • NRCAML
  • NEDCPMD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
microRNA
0.83
cellular component
0.78
transcription factor
0.76
virus perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.99   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 178.99   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
72.4
risk-taking behaviour
2
2
2
60.6
self reported educational attainment
1
1
1
43.8
circadian rhythm
1
1
1
40.1
Myopia
1
1
0
1.3
34.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
72.4
risk-taking behaviour
2
60.6
self reported educational attainment
1
43.8
circadian rhythm
1
40.1
Myopia
0
1.3
34.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neurofascin
VGNC:1347
457660
Macaque
neurofascin
699444
Mouse
MGI:104753
269116
Rat
RGD:620911
116690
Dog
neurofascin
VGNC:43764
488565
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neurofascin
Macaque
neurofascin
Mouse
Rat
Dog
neurofascin
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94856-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Interaction between L1 and Ankyrins
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Immune System
Innate Immune System
Interaction between L1 and Ankyrins
Protein-Protein Interactions (101)
1 – 10 of 101
ANK3
Tbio
Novelty: 0.00429246
Score: 0.992
Data Source: STRINGDB
CNTNAP1
Tbio
Novelty: 0.00618741
Score: 0.992
Data Source: Reactome,STRINGDB
ANK2
Tbio
Novelty: 0.00528351
Score: 0.982
Data Source: Reactome,STRINGDB
DCX
Tbio
Novelty: 0.00077614
Score: 0.978
Data Source: Reactome,STRINGDB
ANK1
Tbio
Novelty: 0.00225305
Score: 0.974
Data Source: Reactome,STRINGDB
KCNQ2
Tclin
Family: IC
Novelty: 0.00209684
Score: 0.974
Data Source: Reactome,STRINGDB
SCN8A
Tclin
Family: IC
Novelty: 0.00203805
Score: 0.972
Data Source: STRINGDB
SPTBN4
Tbio
Novelty: 0.02182293
Score: 0.968
Data Source: STRINGDB
SCN2A
Tclin
Family: IC
Novelty: 0.0007317
Score: 0.965
Data Source: STRINGDB
SDCBP
Tbio
Novelty: 0.00242211
Score: 0.964
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  178.99

PubMed score by year
PubTator Score  85.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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