You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ATF3
Cyclic AMP-dependent transcription factor ATF-3

Protein Summary
Description
This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Represses transcription from promoters with ATF sites. It may repress transcription by stabilizing the binding of inhibitory cofactors at the promoter. Isoform 2 activates transcription presumably by sequestering inhibitory cofactors away from the promoters. This gene encodes a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. This gene is induced by a variety of signals, including many of those encountered by cancer cells, and is involved in the complex process of cellular stress response. Multiple transcript variants encoding different isoforms have been found for this gene. It is possible that alternative splicing of this gene may be physiologically important in the regulation of target genes. [provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000336937
  • ENSP00000336908
  • ENSG00000162772
  • ENST00000341491
  • ENSP00000344352
  • ENST00000366983
  • ENSP00000355950
  • ENST00000366987
  • ENSP00000355954
  • ENST00000464547
  • ENSP00000432208
  • ENST00000613104
  • ENSP00000480606
  • ENST00000613954
  • ENSP00000483576
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
PubMedID
1
virus perturbation
1
small molecule perturbation
0.99
molecular function
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 738.47   (req: < 5)
Gene RIFs: 164   (req: <= 3)
Antibodies: 510   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 738.47   (req: >= 5)
Gene RIFs: 164   (req: > 3)
Antibodies: 510   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (23)
ATF4 activates genes in response to endoplasmic reticulum stress (R-HSA-380994)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF4 activates genes in response to endoplasmic reticulum stress
Reactome
Metabolism of proteins
Reactome
PERK regulates gene expression
Reactome
Unfolded Protein Response (UPR)
Name
Explore in Pharos
Explore in Source
ATF4 activates genes in response to endoplasmic reticulum stress
Metabolism of proteins
PERK regulates gene expression
Unfolded Protein Response (UPR)
Gene Ontology Terms (27)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Genetic Interaction (IGI)
ParkinsonsUK-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (191)
1 – 10 of 191
JUNB
Tbio
Family: TF
Novelty: 0.00841656
p_int: 0.999999909
p_ni: 4.9e-8
p_wrong: 4.2e-8
Score: 0.923
Data Source: BioPlex,STRINGDB
LMO1
Tbio
Novelty: 0.01670419
p_int: 0.999993721
p_ni: 3.9e-8
p_wrong: 0.00000624
Data Source: BioPlex
JUN
Tchem
Family: TF
Novelty: 0.00006856
Score: 0.999
Data Source: STRINGDB
ATF4
Tbio
Family: TF
Novelty: 0.00253408
Score: 0.995
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.976
Data Source: STRINGDB
DDIT3
Tbio
Novelty: 0.00116135
Score: 0.973
Data Source: STRINGDB
DDIT3
Tchem
Family: TF
Novelty: 0.00116135
Score: 0.973
Data Source: STRINGDB
CREB1
Tbio
Family: TF
Novelty: 0.00018059
Score: 0.96
Data Source: STRINGDB
FOS
Tbio
Family: TF
Novelty: 0.00006103
Score: 0.938
Data Source: STRINGDB
SMAD4
Tbio
Family: TF
Novelty: 0.00047069
Score: 0.929
Data Source: STRINGDB
Publication Statistics
PubMed Score  738.47

PubMed score by year
PubTator Score  288.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: