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Tbio
DOK4
Docking protein 4

Protein Summary
Description
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway (By similarity). Putative link with downstream effectors of RET in neuronal differentiation. May be involved in the regulation of the immune response induced by T-cells.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340099
  • ENSP00000344277
  • ENSG00000125170
  • ENST00000569548
  • ENSP00000455128

Symbol
  • IRS5
  • IRS-5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
cell type or tissue
0.62
gene perturbation
0.62
tissue
0.62
small molecule perturbation
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.5   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 221   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.5   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 221   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
2.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
docking protein 4
VGNC:5750
454120
Macaque
docking protein 4
704443
Mouse
MGI:2148865
114255
Rat
RGD:1310084
361364
Dog
docking protein 4
VGNC:40058
487264
Species
Name
OMA
EggNOG
Inparanoid
Chimp
docking protein 4
Macaque
docking protein 4
Mouse
Rat
Dog
docking protein 4
Pathways (4)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
RET signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
RET signaling
Gene Ontology Terms (2)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (70)
1 – 10 of 70
GSE1
Tdark
Novelty: 0.04331197
p_int: 0.999952904
p_ni: 0.000047096
Score: 0.499
Data Source: BioPlex,STRINGDB
HMG20A
Tbio
Family: TF
Novelty: 0.11994252
p_int: 0.999917729
p_ni: 0.000079812
p_wrong: 0.000002459
Score: 0.539
Data Source: BioPlex,STRINGDB
PHKA2
Tbio
Family: Kinase
Novelty: 0.00461145
p_int: 0.999864351
p_ni: 0.0001356
p_wrong: 4.9e-8
Score: 0.734
Data Source: BioPlex,STRINGDB
PHKG2
Tchem
Family: Kinase
Novelty: 0.064884
p_int: 0.999848918
p_ni: 0.000132883
p_wrong: 0.000018199
Score: 0.321
Data Source: BioPlex,STRINGDB
PHKB
Tbio
Family: Enzyme
Novelty: 0.05506418
p_int: 0.999843217
p_ni: 0.000156584
p_wrong: 1.99e-7
Score: 0.613
Data Source: BioPlex,STRINGDB
PBK
Tchem
Family: Kinase
Novelty: 0.00278659
p_int: 0.99967731
p_ni: 0.000322689
Score: 0.271
Data Source: BioPlex,STRINGDB
KBTBD7
Tdark
Novelty: 0.4947466
p_int: 0.99963778
p_ni: 0.000362219
p_wrong: 1e-9
Data Source: BioPlex
AHCYL2
Tbio
Family: Enzyme
Novelty: 0.08695339
p_int: 0.999237875
p_ni: 0.000762125
Data Source: BioPlex
CWC22
Tbio
Novelty: 0.027689
p_int: 0.997763975
p_ni: 0.002236019
p_wrong: 6e-9
Data Source: BioPlex
KBTBD6
Tdark
Novelty: 1.06955768
p_int: 0.997634375
p_ni: 0.002365625
Score: 0.189
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  17.50

PubMed score by year
PubTator Score  14.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer