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Tbio
POMGNT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

Protein Summary
Description
O-linked mannose beta-1,4-N-acetylglucosaminyltransferase that transfers UDP-N-acetyl-D-glucosamine to the 4-position of the mannose to generate N-acetyl-D-glucosamine-beta-1,4-O-D-mannosylprotein. Involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. This gene encodes a protein with glycosyltransferase activity although its function is not currently known. [provided by RefSeq, Sep 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344697
  • ENSP00000344125
  • ENSG00000144647
  • ENST00000441964
  • ENSP00000408992

Symbol
  • AGO61
  • C3orf39
  • EOGTL
  • GTDC2
  • AGO61
  • GTDC2
  • MDDGA8
  • MDDGC8
  • C3orf39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.68
cellular component
0.63
histone modification site profile
0.59
cell type or tissue
0.56
phenotype
0.56


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.72   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 147   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.72   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 147   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
15.5
Cleft palate
1
1
0
1.5
5.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
15.5
Cleft palate
0
1.5
5.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
VGNC:2521
503649
Macaque
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
717032
Mouse
MGI:2143424
215494
Rat
RGD:1304827
316091
Dog
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) [Source:HGNC Symbol;Acc:HGNC:25902]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
Macaque
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)
Mouse
Rat
Dog
protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-) [Source:HGNC Symbol;Acc:HGNC:25902]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8NAT1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
O-linked glycosylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
O-linked glycosylation
Post-translational protein modification
Protein-Protein Interactions (51)
1 – 10 of 51
PECR
Tbio
Family: Enzyme
Novelty: 0.01550165
p_int: 0.999997014
p_ni: 0.000002956
p_wrong: 3e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
SERPINF2
Tbio
Novelty: 0.00054719
p_int: 0.99975874
p_ni: 0.00024126
Data Source: BioPlex
SLC9A6
Tbio
Family: Transporter
Novelty: 0.01410234
p_int: 0.99798093
p_ni: 0.00201907
Data Source: BioPlex
FKBP14
Tbio
Family: Enzyme
Novelty: 0.02742616
p_int: 0.976547609
p_ni: 0.023452387
p_wrong: 4e-9
Score: 0.17
Data Source: BioPlex,STRINGDB
FAM19A2
Tbio
Novelty: 0.28999346
p_int: 0.964869234
p_ni: 0.035130766
Data Source: BioPlex
SCGB2A2
Tbio
Novelty: 0.01594053
p_int: 0.869777987
p_ni: 0.130222013
Data Source: BioPlex
FAM19A4
Tbio
Novelty: 0.04305684
p_int: 0.866919569
p_ni: 0.133080431
Data Source: BioPlex
NOB1
Tbio
Novelty: 0.01209681
p_int: 0.859753627
p_ni: 0.139928741
p_wrong: 0.000317632
Score: 0.157
Data Source: BioPlex,STRINGDB
DPP6
Tbio
Family: Enzyme
Novelty: 0.00435138
p_int: 0.848550223
p_ni: 0.151449777
Data Source: BioPlex
PLAUR
Tchem
Family: Enzyme
Novelty: 0.00087642
p_int: 0.833923071
p_ni: 0.166076929
Data Source: BioPlex
Publication Statistics
PubMed Score  7.72

PubMed score by year
PubTator Score  5.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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