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Tbio
CDH5
Cadherin-5

Protein Summary
Description
Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341529
  • ENSP00000344115
  • ENSG00000179776
  • ENST00000614547
  • ENSP00000479381
  • ENST00000649567
  • ENSP00000497290

Symbol
  • 7B4
  • CD144
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.85
protein domain
0.85
tissue sample
0.74
gene perturbation
0.67
microRNA
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1341.27   (req: < 5)
Gene RIFs: 187   (req: <= 3)
Antibodies: 1071   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1341.27   (req: >= 5)
Gene RIFs: 187   (req: > 3)
Antibodies: 1071   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
2
2
21.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
21.3
Pathways (87)
Adherens junctions interactions (R-HSA-418990)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adherens junctions interactions
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-cell junction organization
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Adherens junctions interactions
Cell junction organization
Cell-Cell communication
Cell-cell junction organization
Signal Transduction
Gene Ontology Terms (28)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (293)
1 – 10 of 293
ARVCF
Tbio
Novelty: 0.03248592
p_int: 0.9999996
p_ni: 3.99e-7
p_wrong: 1e-9
Score: 0.413
Data Source: BioPlex,STRINGDB
PKP4
Tbio
Novelty: 0.03654703
p_int: 0.999998964
p_ni: 0.000001035
p_wrong: 1e-9
Score: 0.628
Data Source: BioPlex,STRINGDB
SCML1
Tdark
Novelty: 0.60106322
p_int: 0.999984618
p_ni: 0.000007986
p_wrong: 0.000007396
Data Source: BioPlex
CTNNA2
Tbio
Novelty: 0.00783865
p_int: 0.999967386
p_ni: 0.000032614
Score: 0.27
Data Source: BioPlex,STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
p_int: 0.999923201
p_ni: 0.000076799
Score: 0.988
Data Source: BioPlex,STRINGDB
RBFA
Tbio
Novelty: 0.1061138
p_int: 0.999695281
p_ni: 0.000166668
p_wrong: 0.000138051
Data Source: BioPlex
CTNNA1
Tbio
Novelty: 0.00925774
p_int: 0.999673601
p_ni: 0.000326399
Score: 0.95
Data Source: BioPlex,Reactome,STRINGDB
SARAF
Tbio
Novelty: 0.0383833
p_int: 0.999653218
p_ni: 0.000345354
p_wrong: 0.000001429
Data Source: BioPlex
PLD1
Tchem
Family: Enzyme
Novelty: 0.00608142
p_int: 0.999629784
p_ni: 0.000370216
Data Source: BioPlex
TMTC3
Tdark
Novelty: 0.17411457
p_int: 0.999628636
p_ni: 0.000371233
p_wrong: 1.32e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1341.27

PubMed score by year
PubTator Score  755.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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