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Tchem
CCR6
C-C chemokine receptor type 6

Protein Summary
Description
Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune respon ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341935
  • ENSP00000343952
  • ENSG00000112486
  • ENST00000349984
  • ENSP00000339393
  • ENST00000400926
  • ENSP00000383715
  • ENST00000643861
  • ENSP00000493637

Symbol
  • CKRL3
  • CMKBR6
  • GPR29
  • STRL22
  • BN-1
  • DCR2
  • DRY6
  • CCR-6
  • CD196
  • CKRL3
  • GPR29
  • CKR-L3
  • CMKBR6
  • GPRCY4
  • STRL22
  • CC-CKR-6
  • C-C CKR-6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.86
gene perturbation
0.76
PubMedID
0.76
phenotype
0.75
ligand (protein)
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.27   (req: < 5)
Gene RIFs: 135   (req: <= 3)
Antibodies: 771   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.27   (req: >= 5)
Gene RIFs: 135   (req: > 3)
Antibodies: 771   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 4
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
4
3
1.2
98.9
eosinophil count
1
1
1
43.5
triglyceride measurement
1
1
0
1.5
33.9
serum non-albumin protein measurement
1
1
1
9.4
albumin:globulin ratio measurement
1
1
1
9.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.2
98.9
eosinophil count
1
43.5
triglyceride measurement
0
1.5
33.9
serum non-albumin protein measurement
1
9.4
albumin:globulin ratio measurement
1
9.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
C-C motif chemokine receptor 6
574335
Mouse
MGI:1333797
12458
Rat
RGD:1308562
308163
Dog
C-C motif chemokine receptor 6
VGNC:38914
484080
Horse
C-C motif chemokine receptor 6
VGNC:16228
100055159
Species
Name
OMA
EggNOG
Inparanoid
Macaque
C-C motif chemokine receptor 6
Mouse
Rat
Dog
C-C motif chemokine receptor 6
Horse
C-C motif chemokine receptor 6
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P51684-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Beta defensins
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Defensins
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Beta defensins
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
Defensins
Gene Ontology Terms (34)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (269)
1 – 10 of 269
MCOLN1
Tchem
Family: IC
Novelty: 0.00442768
p_int: 0.999996525
p_ni: 0.000003341
p_wrong: 1.34e-7
Data Source: BioPlex
PODXL
Tbio
Novelty: 0.00306913
p_int: 0.999965094
p_ni: 0.000034906
Data Source: BioPlex
TMEM161B
Tbio
Novelty: 0.27823549
p_int: 0.999709147
p_ni: 0.000280861
p_wrong: 0.000009991
Data Source: BioPlex
ATP2B4
Tbio
Family: Transporter
Novelty: 0.00560356
p_int: 0.999522301
p_ni: 0.000477699
Data Source: BioPlex
ATP9A
Tbio
Family: Transporter
Novelty: 0.15755352
p_int: 0.999518927
p_ni: 0.000480833
p_wrong: 2.41e-7
Data Source: BioPlex
GPR89A
Tbio
Family: IC
Novelty: 0.06782776
p_int: 0.999144692
p_ni: 0.000855308
Data Source: BioPlex
ABCB1
Tchem
Family: Transporter
Novelty: 0.00018144
p_int: 0.997898888
p_ni: 0.001726548
p_wrong: 0.000374564
Score: 0.23
Data Source: BioPlex,STRINGDB
ITPR2
Tbio
Family: IC
Novelty: 0.00619813
p_int: 0.99775619
p_ni: 0.00224381
Data Source: BioPlex
SLC30A5
Tbio
Family: Transporter
Novelty: 0.02432633
p_int: 0.996833753
p_ni: 0.003002251
p_wrong: 0.000163996
Data Source: BioPlex
LPCAT3
Tbio
Family: Enzyme
Novelty: 0.00485213
p_int: 0.996678683
p_ni: 0.003321164
p_wrong: 1.53e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  351.27

PubMed score by year
PubTator Score  289.09

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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