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Tbio
HOXA9
Homeobox protein Hox-A9

Protein Summary
Description
Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Required for induction of E-selectin and VCAM-1, on the endothelial cells surface at sites of inflammation. In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is highly similar to the abdominal-B (Abd-B) gene of Drosophila. A specific translocation event which causes a fusion between this gene and the NUP98 gene has been associated with myeloid leukemogenesis. Read-through transcription exists between this gene and the upstream ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343483
  • ENSP00000343619
  • ENSG00000078399

Symbol
  • HOX1G
  • HOX1
  • ABD-B
  • HOX1G
  • HOX1.7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
protein domain
0.85
biological process
0.75
microRNA
0.66
biological term
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.92   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 324   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.92   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
1
1
74.5
mosaic loss of chromosome Y measurement
2
1
2
73.4
mean corpuscular hemoglobin concentration
1
1
1
68.8
heel bone mineral density
1
1
1
60.5
platelet crit
1
1
1
27
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell density measurement
1
74.5
mosaic loss of chromosome Y measurement
2
73.4
mean corpuscular hemoglobin concentration
1
68.8
heel bone mineral density
1
60.5
platelet crit
1
27
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
homeobox A10
704713
Mouse
MGI:96180
15405
Rat
RGD:1310001
297099
Dog
homeobox A9
VGNC:54770
482372
Horse
homeobox A9
100629587
Species
Name
OMA
EggNOG
Inparanoid
Macaque
homeobox A10
Mouse
Rat
Dog
homeobox A9
Horse
homeobox A9
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P31269-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (136)
1 – 10 of 136
PBX1
Tbio
Family: TF
Novelty: 0.00329442
Score: 0.989
Data Source: STRINGDB
MEIS1
Tbio
Family: TF
Novelty: 0.00480433
Score: 0.962
Data Source: STRINGDB
PBX3
Tbio
Family: TF
Novelty: 0.01516183
Score: 0.929
Data Source: STRINGDB
PBX2
Tbio
Family: TF
Novelty: 0.01339291
Score: 0.895
Data Source: STRINGDB
MLLT3
Tbio
Novelty: 0.00361056
Score: 0.867
Data Source: STRINGDB
HOXA10
Tbio
Family: TF
Novelty: 0.00324357
Score: 0.855
Data Source: STRINGDB
NUP98
Tbio
Family: Enzyme
Novelty: 0.00401452
Score: 0.791
Data Source: STRINGDB
SUZ12
Tbio
Novelty: 0.00402353
Score: 0.771
Data Source: STRINGDB
MLLT1
Tbio
Novelty: 0.00328241
Score: 0.765
Data Source: STRINGDB
MSI2
Tbio
Novelty: 0.01716735
Score: 0.748
Data Source: STRINGDB
Publication Statistics
PubMed Score  397.92

PubMed score by year
PubTator Score  206.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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