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Tchem
USP1
Ubiquitin carboxyl-terminal hydrolase 1

Protein Summary
Description
Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2 (PubMed:15694335). Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA (PubMed:16531995). Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity (PubMed:18082604, PubMed:26388029). This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339950
  • ENSP00000343526
  • ENSG00000162607
  • ENST00000371146
  • ENSP00000360188

Symbol
  • UBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.96
transcription factor binding site profile
0.91
disease perturbation
0.9
small molecule perturbation
0.9
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 112   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
1
1
1
88.7
mean corpuscular hemoglobin concentration
1
1
1
78.9
triglyceride measurement
1
1
1
69.3
red blood cell density measurement
1
1
1
68.8
metabolic syndrome
1
1
1
49.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
1
88.7
mean corpuscular hemoglobin concentration
1
78.9
triglyceride measurement
1
69.3
red blood cell density measurement
1
68.8
metabolic syndrome
1
49.6
Pathways (8)
DNA Damage Bypass (R-HSA-73893)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Damage Bypass
Reactome
DNA Repair
Reactome
Fanconi Anemia Pathway
Reactome
Recognition of DNA damage by PCNA-containing replication complex
Name
Explore in Pharos
Explore in Source
DNA Damage Bypass
DNA Repair
Fanconi Anemia Pathway
Recognition of DNA damage by PCNA-containing replication complex
Protein-Protein Interactions (185)
1 – 10 of 185
PTGES2
Tchem
Family: Enzyme
Novelty: 0.01415352
p_int: 0.996239394
p_ni: 0.003760606
Data Source: BioPlex
STAT2
Tbio
Family: TF
Novelty: 0.00241454
p_int: 0.987073464
p_ni: 0.012926535
Score: 0.205
Data Source: BioPlex,STRINGDB
OPALIN
Tdark
Novelty: 0.08221612
p_int: 0.984416787
p_ni: 0.015583213
Data Source: BioPlex
WDR48
Tbio
Novelty: 0.04070481
p_int: 0.959785846
p_ni: 0.040214154
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PHLPP1
Tchem
Family: Enzyme
Novelty: 0.00747239
p_int: 0.943165926
p_ni: 0.056831754
p_wrong: 0.00000232
Score: 0.606
Data Source: BioPlex,STRINGDB
MGARP
Tbio
Novelty: 0.02883753
p_int: 0.911888481
p_ni: 0.088111519
Data Source: BioPlex
RAD51AP1
Tbio
Novelty: 0.04859066
p_int: 0.88575481
p_ni: 0.11424519
Score: 0.901
Data Source: BioPlex,STRINGDB
CHIC1
Tdark
Novelty: 0.06718561
p_int: 0.866057445
p_ni: 0.133942555
Data Source: BioPlex
LRRC15
Tbio
Novelty: 0.03701624
p_int: 0.824143102
p_ni: 0.175851623
p_wrong: 0.000005275
Data Source: BioPlex
FANCD2
Tbio
Novelty: 0.00316101
Score: 0.992
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  112.00

PubMed score by year
PubTator Score  83.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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