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Tbio
TNFSF13
Tumor necrosis factor ligand superfamily member 13

Protein Summary
Description
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. Plays a role in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338784
  • ENSP00000343505
  • ENSG00000161955
  • ENST00000349228
  • ENSP00000314455
  • ENST00000396542
  • ENSP00000379792
  • ENST00000396545
  • ENSP00000379794
  • ENST00000625791
  • ENSP00000486052

Symbol
  • APRIL
  • TALL2
  • ZTNF2
  • APRIL
  • CD256
  • TALL2
  • ZTNF2
  • TALL-2
  • TNLG7B
  • TRDL-1
  • UNQ383/PRO715
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.91
PubMedID
0.79
cellular component
0.72
transcription factor
0.62
biological process
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.79   (req: < 5)
Gene RIFs: 154   (req: <= 3)
Antibodies: 714   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28.79   (req: >= 5)
Gene RIFs: 154   (req: > 3)
Antibodies: 714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (11)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
HuR (ELAVL1) binds and stabilizes mRNA
Reactome
Immune System
Reactome
Metabolism of RNA
Reactome
Regulation of mRNA stability by proteins that bind AU-rich elements
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
HuR (ELAVL1) binds and stabilizes mRNA
Immune System
Metabolism of RNA
Regulation of mRNA stability by proteins that bind AU-rich elements
Protein-Protein Interactions (28)
1 – 10 of 28
TNFRSF13B
Tbio
Novelty: 0.00443808
Score: 0.98
Data Source: Reactome,STRINGDB
TNFRSF17
Tbio
Novelty: 0.00587499
Score: 0.975
Data Source: Reactome,STRINGDB
TRAF5
Tbio
Novelty: 0.01881484
Score: 0.918
Data Source: STRINGDB
TRAF3
Tbio
Novelty: 0.00292884
Score: 0.916
Data Source: STRINGDB
TRAF6
Tbio
Novelty: 0.00159491
Score: 0.91
Data Source: STRINGDB
TRAF2
Tbio
Novelty: 0.01051586
Score: 0.905
Data Source: STRINGDB
ELAVL1
Tchem
Novelty: 0.00158015
Score: 0.9
Data Source: STRINGDB
ANP32A
Tbio
Novelty: 0.00662859
Score: 0.9
Data Source: STRINGDB
SET
Tbio
Novelty: 0.00254126
Score: 0.9
Data Source: STRINGDB
NUP214
Tbio
Novelty: 0.01202485
Score: 0.9
Data Source: STRINGDB
Publication Statistics
PubMed Score  28.79

PubMed score by year
PubTator Score  159.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGG
1-70
PSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQP
70-140
ALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNS
140-210
CYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL
210-250
MPASSPFLLAPKGPPGNMGGPVREPALSVALWLSWGAALGAVACAMALLTQQTELQSLRREVSRLQGTGGPSQNGEGYPWQSLPEQSSDALEAWENGERSRKRRAVLTQKQKKQHSVLHLVPINATSKDDSDVTEVMWQPALRRGRGLQAQGYGVRIQDAGVYLLYSQVLFQDVTFTMGQVVSREGQGRQETLFRCIRSMPSHPDRAYNSCYSAGVFHLHQGDILSVIIPRARAKLNLSPHGTFLGFVKL