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Tbio
LIPI
Lipase member I

Protein Summary
Description
Hydrolyzes specifically phosphatidic acid (PA) to produce 2-acyl lysophosphatidic acid (LPA; a potent bioactive lipid mediator) and fatty acid. Does not hydrolyze other phospholipids, like phosphatidylserine (PS), phosphatidylcholine (PC) and phosphatidylethanolamine (PE) or triacylglycerol (TG). The protein encoded by this gene is a phospholipase that hydrolyzes phosphatidic acid to produce lysophosphatidic acid. Defects in this gene are a cause of susceptibility to familial hypertrigliceridemia. This gene is also expressed at high levels in Ewing family tumor cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344577
  • ENSP00000343331
  • ENSG00000188992

Symbol
  • LPDL
  • CT17
  • LPDL
  • PLA1C
  • PRED5
  • mPA-PLA1 beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.65
cell type or tissue
0.61
protein domain
0.58
tissue
0.52
molecular function
0.49


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.18   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 91   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 188.18   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 91   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipase I
VGNC:7198
742726
Rat
RGD:1310162
288322
Dog
lipase I
VGNC:42698
608069
Platypus
lipase I
100081695
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipase I
Rat
Dog
lipase I
Platypus
lipase I
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6XZB0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (5)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PA
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PA
Gene Ontology Terms (8)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (48)
1 – 10 of 48
GAS2L2
Tdark
Novelty: 0.26280072
Score: 0.8
Data Source: STRINGDB
GAS2
Tbio
Novelty: 0.01462404
Score: 0.743
Data Source: STRINGDB
PHKA1
Tbio
Family: Kinase
Novelty: 0.02895127
Score: 0.737
Data Source: STRINGDB
APOA5
Tbio
Novelty: 0.00232222
Score: 0.722
Data Source: STRINGDB
SPA17
Tbio
Novelty: 0.02632554
Score: 0.719
Data Source: STRINGDB
GAS2L1
Tbio
Novelty: 0.17484834
Score: 0.716
Data Source: STRINGDB
HSPA13
Tbio
Novelty: 0.03895652
Score: 0.71
Data Source: STRINGDB
ACRBP
Tbio
Novelty: 0.01158059
Score: 0.7
Data Source: STRINGDB
PRSS50
Tbio
Family: Enzyme
Novelty: 0.01511883
Score: 0.687
Data Source: STRINGDB
ZBTB21
Tbio
Family: TF
Novelty: 0.16032292
Score: 0.671
Data Source: STRINGDB
Publication Statistics
PubMed Score  188.18

PubMed score by year
PubTator Score  20.36

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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