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Tclin
JAK1
Tyrosine-protein kinase JAK1

Protein Summary
Description
Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway (PubMed:7615558). Kinase partner for the interleukin (IL)-2 receptor (PubMed:11909529). This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342505
  • ENSP00000343204
  • ENSG00000162434

Symbol
  • JAK1A
  • JAK1B
  • JTK3
  • JAK1A
  • JAK1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
protein domain
1
virus perturbation
1
molecular function
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 618.43   (req: < 5)
Gene RIFs: 175   (req: <= 3)
Antibodies: 565   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 618.43   (req: >= 5)
Gene RIFs: 175   (req: > 3)
Antibodies: 565   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2671
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 7
Protein Data Bank (30)
1 – 5 of 30
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (149)
Antiviral mechanism by IFN-stimulated genes (R-HSA-1169410)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 37
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antiviral mechanism by IFN-stimulated genes
Reactome
Cytokine Signaling in Immune system
Reactome
FLT3 Signaling
Reactome
IL-6-type cytokine receptor ligand interactions
Reactome
ISG15 antiviral mechanism
Name
Explore in Pharos
Explore in Source
Antiviral mechanism by IFN-stimulated genes
Cytokine Signaling in Immune system
FLT3 Signaling
IL-6-type cytokine receptor ligand interactions
ISG15 antiviral mechanism
Gene Ontology Terms (34)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (363)
1 – 10 of 363
IFNLR1
Tbio
Novelty: 0.02567087
p_int: 0.999980493
p_ni: 0.000019507
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
IL4R
Tclin
Novelty: 0.00547841
p_int: 0.998786542
p_ni: 0.001213458
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
OSMR
Tbio
Novelty: 0.02057578
p_int: 0.97650127
p_ni: 0.02349873
Score: 0.962
Data Source: BioPlex,Reactome,STRINGDB
TGFBR2
Tchem
Family: Kinase
Novelty: 0.00128741
p_int: 0.974123871
p_ni: 0.025876129
Score: 0.241
Data Source: BioPlex,STRINGDB
LAMP2
Tbio
Novelty: 0.00223951
p_int: 0.959319667
p_ni: 0.040680333
Data Source: BioPlex
CMKLR1
Tchem
Family: GPCR
Novelty: 0.00748603
p_int: 0.955405947
p_ni: 0.044594053
Data Source: BioPlex
LAMP3
Tbio
Novelty: 0.02024311
p_int: 0.952606992
p_ni: 0.047393008
Data Source: BioPlex
IL13RA2
Tbio
Novelty: 0.04900852
p_int: 0.946287365
p_ni: 0.053712635
Score: 0.855
Data Source: BioPlex,STRINGDB
IFNGR1
Tbio
Novelty: 0.00552398
p_int: 0.89478986
p_ni: 0.10521014
Score: 0.979
Data Source: BioPlex,Reactome,STRINGDB
MANSC1
Tdark
Novelty: 1.42372881
p_int: 0.893939132
p_ni: 0.106060868
Data Source: BioPlex
Publication Statistics
PubMed Score  618.43

PubMed score by year
PubTator Score  723.39

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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