You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SERPINA6
Corticosteroid-binding globulin

Protein Summary
Description
Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341584
  • ENSP00000342850
  • ENSG00000170099
  • ENST00000621384
  • ENSP00000484501
  • ENSG00000277405

Symbol
  • CBG
  • CBG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.81
cell type or tissue
0.76
disease
0.63
gene perturbation
0.6
biological term
0.55


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1849.46   (req: < 5)
Gene RIFs: 41   (req: <= 3)
Antibodies: 452   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1849.46   (req: >= 5)
Gene RIFs: 41   (req: > 3)
Antibodies: 452   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 12
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortisol measurement
1
1
1
4.8
platelet count
1
1
1
2.7
triglyceride measurement
1
1
1
1.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cortisol measurement
1
4.8
platelet count
1
2.7
triglyceride measurement
1
1.1
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (57)
1 – 10 of 57
DHFR2
Tbio
Family: Enzyme
Novelty: 0.02374466
p_int: 0.999549682
p_ni: 0.000450317
Score: 0.187
Data Source: BioPlex,STRINGDB
COCH
Tbio
Novelty: 0.00819355
p_int: 0.801460902
p_ni: 0.198539098
Score: 0.212
Data Source: BioPlex,STRINGDB
PAM
Tchem
Family: Enzyme
Novelty: 0.00378397
p_int: 0.799880681
p_ni: 0.200109358
p_wrong: 0.000009961
Score: 0.345
Data Source: BioPlex,STRINGDB
SHBG
Tchem
Novelty: 0.00015978
Score: 0.839
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.785
Data Source: STRINGDB
CORT
Tbio
Novelty: 0.00789975
Score: 0.744
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.73
Data Source: STRINGDB
NR3C1
Tclin
Family: NR
Novelty: 0.00029396
Score: 0.672
Data Source: STRINGDB
HSD17B6
Tbio
Family: Enzyme
Novelty: 0.01428594
Score: 0.64
Data Source: STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.618
Data Source: STRINGDB
Publication Statistics
PubMed Score  1849.46

PubMed score by year
PubTator Score  828.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: