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Tclin
HRH3
Histamine H3 receptor

Protein Summary
Description
The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization. Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. This gene encodes one of the histamine receptors (H3) which belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and can regulate neurotransmitter release. This receptor can also increase voltage-dependent calcium current in smooth muscles and innervates the blood vessels and the heart in cardiovascular system. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340177
  • ENSP00000342560
  • ENSG00000101180

Symbol
  • GPCR97
  • HH3R
  • GPCR97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
0.98
biological process
0.95
disease perturbation
0.74
chemical
0.64
molecular function
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 668.24   (req: < 5)
Gene RIFs: 40   (req: <= 3)
Antibodies: 434   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 668.24   (req: >= 5)
Gene RIFs: 40   (req: > 3)
Antibodies: 434   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2413
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4
Pathways (12)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (18)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (292)
1 – 10 of 292
MCHR2
Tchem
Family: GPCR
Novelty: 0.01191922
Score: 0.953
Data Source: STRINGDB
GRM4
Tchem
Family: GPCR
Novelty: 0.00380434
Score: 0.949
Data Source: STRINGDB
HTR5A
Tchem
Family: GPCR
Novelty: 0.0160551
Score: 0.947
Data Source: STRINGDB
GRM3
Tchem
Family: GPCR
Novelty: 0.00340947
Score: 0.945
Data Source: STRINGDB
GNG3
Tbio
Novelty: 0.16941216
Score: 0.941
Data Source: STRINGDB
GNG13
Tbio
Novelty: 0.13011919
Score: 0.94
Data Source: STRINGDB
HTR1A
Tclin
Family: GPCR
Novelty: 0.00015658
Score: 0.938
Data Source: STRINGDB
PDYN
Tbio
Novelty: 0.00039564
Score: 0.938
Data Source: STRINGDB
HTR1E
Tchem
Family: GPCR
Novelty: 0.02160816
Score: 0.937
Data Source: STRINGDB
GRM8
Tchem
Family: GPCR
Novelty: 0.00827879
Score: 0.936
Data Source: STRINGDB
Publication Statistics
PubMed Score  668.24

PubMed score by year
PubTator Score  344.49

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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