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Tbio
SLC25A15
Mitochondrial ornithine transporter 1

Protein Summary
Description
Ornithine-citrulline antiporter. Connects the cytosolic and the intramitochondrial reactions of the urea cycle by exchanging cytosolic ornithine with matrix citrulline (PubMed:12807890). The stoichiometry is close to 1:1 (By similarity). This gene is a member of the mitochondrial carrier family. The encoded protein transports ornithine across the inner mitochondrial membrane from the cytosol to the mitochondrial matrix. The protein is an essential component of the urea cycle, and functions in ammonium detoxification and biosynthesis of the amino acid arginine. Mutations in this gene result in hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome. There is a pseudogene of this locus on the Y chromosome.[provided by RefSeq, May 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338625
  • ENSP00000342267
  • ENSG00000102743

Symbol
  • ORC1
  • ORNT1
  • HHH
  • ORC1
  • ORNT1
  • D13S327
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
histone modification site profile
0.83
microRNA
0.67
transcription factor binding site profile
0.64
cellular component
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.96   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 64   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.96   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 64   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
1
1
1
46.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil count
1
46.8
Pathways (26)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Urea cycle
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amino acids and derivatives
Urea cycle
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Protein-Protein Interactions (60)
1 – 10 of 60
IGHA2
Tbio
p_int: 0.998698276
p_ni: 0.001301711
p_wrong: 1.3e-8
Data Source: BioPlex
GLMP
Tdark
Novelty: 0.10163099
p_int: 0.994743424
p_ni: 0.005256575
p_wrong: 1e-9
Data Source: BioPlex
C4BPB
Tbio
Novelty: 0.0924866
p_int: 0.950014492
p_ni: 0.049985431
p_wrong: 7.8e-8
Score: 0.19
Data Source: BioPlex,STRINGDB
HLA-DPA1
Tbio
Novelty: 0.01080446
p_int: 0.946220757
p_ni: 0.053779238
p_wrong: 5e-9
Data Source: BioPlex
JCHAIN
Tbio
Novelty: 0.00172454
p_int: 0.946216951
p_ni: 0.01132231
p_wrong: 0.04246074
Score: 0.181
Data Source: BioPlex,STRINGDB
FAM131B
Tdark
Novelty: 0.3424123
p_int: 0.94313226
p_ni: 0.056859617
p_wrong: 0.000008124
Data Source: BioPlex
NRBP1
Tbio
Family: Kinase
Novelty: 0.05902656
p_int: 0.937419534
p_ni: 0.062580372
p_wrong: 9.4e-8
Data Source: BioPlex
KLK1
Tchem
Family: Enzyme
Novelty: 0.00190157
p_int: 0.930762924
p_ni: 0.069234563
p_wrong: 0.000002513
Data Source: BioPlex
PDCD1
Tclin
Novelty: 0.000448
p_int: 0.86629547
p_ni: 0.133700631
p_wrong: 0.000003899
Data Source: BioPlex
VSIG4
Tbio
Novelty: 0.01671671
p_int: 0.822871708
p_ni: 0.17712828
p_wrong: 1.3e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  83.96

PubMed score by year
PubTator Score  43.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer