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Tbio
CAV3
Caveolin-3

Protein Summary
Description
May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (PubMed:19262564). This gene encodes a caveolin family member, which functions as a component of the caveolae plasma membranes found in most cell types. Caveolin proteins are proposed to be scaffolding proteins for organizing and concentrating certain caveolin-interacting molecules. Mutations identified in this gene lead to interference with protein oligomerization or intra-cellular routing, disrupting caveolae formation and resulting in Limb-Girdle muscular dystrophy type-1C (LGMD-1C), hyperCKemia or rippling muscle disease (RMD). Alt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343849
  • ENSP00000341940
  • ENSG00000182533
  • ENST00000397368
  • ENSP00000380525

Symbol
  • LQT9
  • MPDT
  • RMD2
  • VIP21
  • LGMD1C
  • VIP-21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
cell type or tissue
0.84
molecular function
0.79
cellular component
0.75
biological term
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 508.41   (req: < 5)
Gene RIFs: 77   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 508.41   (req: >= 5)
Gene RIFs: 77   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 72
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
0
1.1
55.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1.1
55.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
caveolin 3
VGNC:1753
738786
Macaque
caveolin 3
702163
Mouse
MGI:107570
12391
Rat
RGD:2281
29161
Dog
caveolin 3
VGNC:38753
484671
Species
Name
OMA
EggNOG
Inparanoid
Chimp
caveolin 3
Macaque
caveolin 3
Mouse
Rat
Dog
caveolin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P56539-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Smooth Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Smooth Muscle Contraction
Gene Ontology Terms (87)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (243)
1 – 10 of 243
ANKRD13C
Tbio
Novelty: 1.5309683
p_int: 0.999999058
p_ni: 9.42e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
ENDOD1
Tdark
Family: Enzyme
Novelty: 0.26430864
p_int: 0.999998886
p_ni: 0.000001114
Data Source: BioPlex
SARM1
Tbio
Novelty: 0.00510488
p_int: 0.999993235
p_ni: 0.000006765
Data Source: BioPlex
CEP95
Tdark
Novelty: 1.18897795
p_int: 0.99999226
p_ni: 0.000007615
p_wrong: 1.25e-7
Score: 0.187
Data Source: BioPlex,STRINGDB
CENPT
Tbio
Novelty: 0.03878936
p_int: 0.999984769
p_ni: 0.000015161
p_wrong: 7e-8
Score: 0.19
Data Source: BioPlex,STRINGDB
MIS18BP1
Tbio
Novelty: 0.05688807
p_int: 0.999983346
p_ni: 0.000016645
p_wrong: 1e-8
Score: 0.663
Data Source: BioPlex,STRINGDB
MCM10
Tbio
Novelty: 0.0136058
p_int: 0.999946879
p_ni: 0.000053121
Data Source: BioPlex
CAV1
Tbio
Novelty: 0.00035244
p_int: 0.999885841
p_ni: 0.000113977
p_wrong: 1.83e-7
Score: 0.825
Data Source: BioPlex,STRINGDB
GTSE1
Tbio
Family: Enzyme
Novelty: 0.0460569
p_int: 0.999832601
p_ni: 0.000167399
Score: 0.185
Data Source: BioPlex,STRINGDB
REEP1
Tbio
Novelty: 0.02280713
p_int: 0.999792003
p_ni: 0.000066016
p_wrong: 0.000141981
Score: 0.527
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  508.41

PubMed score by year
PubTator Score  311.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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