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Tbio
CYB5A
Cytochrome b5

Protein Summary
Description
Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340533
  • ENSP00000341625
  • ENSG00000166347
  • ENST00000397914
  • ENSP00000381011
  • ENST00000494131
  • ENSP00000436461

Symbol
  • CYB5
  • CYB5
  • MCB5
  • METAG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
transcription factor perturbation
0.91
cellular component
0.9
kinase perturbation
0.88
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2011.66   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 338   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2011.66   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 338   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
3
4
97.2
testosterone measurement
1
2
2
95.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
97.2
testosterone measurement
2
95.9
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (56)
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane (R-HSA-9609523)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Reactome
Metabolism
Reactome
Metabolism of vitamins and cofactors
Reactome
Metabolism of water-soluble vitamins and cofactors
Reactome
Protein localization
Name
Explore in Pharos
Explore in Source
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Metabolism
Metabolism of vitamins and cofactors
Metabolism of water-soluble vitamins and cofactors
Protein localization
Protein-Protein Interactions (107)
1 – 10 of 107
ENDOD1
Tdark
Family: Enzyme
Novelty: 0.26430864
p_int: 0.995702313
p_ni: 0.003856802
p_wrong: 0.000440885
Score: 0.189
Data Source: BioPlex,STRINGDB
HSPA14
Tbio
Novelty: 0.01714625
p_int: 0.991417582
p_ni: 0.008579967
p_wrong: 0.000002451
Score: 0.224
Data Source: BioPlex,STRINGDB
RABGAP1L
Tbio
Family: Enzyme
Novelty: 0.2377644
p_int: 0.977353759
p_ni: 0.022645789
p_wrong: 4.52e-7
Score: 0.166
Data Source: BioPlex,STRINGDB
AGPAT4
Tbio
Family: Enzyme
Novelty: 0.10376004
p_int: 0.952828701
p_ni: 0.047171297
p_wrong: 1e-9
Score: 0.289
Data Source: BioPlex,STRINGDB
TAB1
Tchem
Family: Kinase
Novelty: 0.00721424
p_int: 0.948614067
p_ni: 0.051385932
Score: 0.216
Data Source: BioPlex,STRINGDB
BCAP31
Tbio
Novelty: 0.01363316
p_int: 0.851396712
p_ni: 0.148603288
Score: 0.554
Data Source: BioPlex,STRINGDB
SNX2
Tbio
Novelty: 0.03880384
p_int: 0.775555575
p_ni: 0.224444425
Score: 0.172
Data Source: BioPlex,STRINGDB
CYB5R3
Tbio
Family: Enzyme
Novelty: 0.00774258
Score: 0.995
Data Source: Reactome,STRINGDB
POR
Tbio
Family: Enzyme
Novelty: 0.00145147
Score: 0.964
Data Source: STRINGDB
CYCS
Tchem
Novelty: 0.00014004
Score: 0.947
Data Source: STRINGDB
Publication Statistics
PubMed Score  2011.66

PubMed score by year
PubTator Score  727.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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