You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SMAD4
Mothers against decapentaplegic homolog 4

Protein Summary
Description
In muscle physiology, plays a central role in the balance between atrophy and hypertrophy. When recruited by MSTN, promotes atrophy response via phosphorylated SMAD2/4. MSTN decrease causes SMAD4 release and subsequent recruitment by the BMP pathway to promote hypertrophy via phosphorylated SMAD1/5/8. Acts synergistically with SMAD1 and YY1 in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression. Binds to SMAD binding elements (SBEs) (5'-GTCT/AGAC-3') within BMP response element (BMPRE) of cardiac activating regions (By similarity). Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling (PubMed:25514493). Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the mul ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000342988
  • ENSP00000341551
  • ENSG00000141646
  • ENST00000398417
  • ENSP00000381452

Symbol
  • DPC4
  • MADH4
  • JIP
  • DPC4
  • MADH4
  • MYHRS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
interacting protein
0.96
kinase perturbation
0.95


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2033.84   (req: < 5)
Gene RIFs: 424   (req: <= 3)
Antibodies: 815   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2033.84   (req: >= 5)
Gene RIFs: 424   (req: > 3)
Antibodies: 815   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 88
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Eczema
1
1
0
1
48
1
1
0
1
48
childhood onset asthma
1
1
0
1.1
4.8
1
1
0
1.1
2.9
platelet crit
1
1
1
0.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Eczema
0
1
48
0
1
48
childhood onset asthma
0
1.1
4.8
0
1.1
2.9
platelet crit
1
0.8
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (109)
Deubiquitination (R-HSA-5688426)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Deubiquitination
Reactome
Developmental Biology
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Name
Explore in Pharos
Explore in Source
Deubiquitination
Developmental Biology
Disease
Diseases of signal transduction
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Gene Ontology Terms (97)
Items per page:
10
1 – 10 of 17
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
CAFA
Protein-Protein Interactions (490)
1 – 10 of 490
SKIL
Tbio
Novelty: 0.00788464
p_int: 0.999999999
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
SKI
Tbio
Novelty: 0.02109924
p_int: 0.999999955
p_ni: 2.7e-8
p_wrong: 1.8e-8
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
LHX4
Tbio
Family: TF
Novelty: 0.02047732
p_int: 0.999999798
p_wrong: 2.02e-7
Score: 0.344
Data Source: BioPlex,STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
p_int: 0.999703251
p_ni: 0.00005911
p_wrong: 0.00023764
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
STXBP4
Tbio
Novelty: 0.08831326
p_int: 0.997910054
p_ni: 0.001522325
p_wrong: 0.000567621
Data Source: BioPlex
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.997
Data Source: Reactome,STRINGDB
THOC5
Tbio
Novelty: 0.04618391
Score: 0.993
Data Source: STRINGDB
TGFBR1
Tchem
Family: Kinase
Novelty: 0.00081645
Score: 0.991
Data Source: STRINGDB
TGFBRAP1
Tbio
Novelty: 0.05996919
Score: 0.99
Data Source: STRINGDB
TGFBR2
Tchem
Family: Kinase
Novelty: 0.00085381
Score: 0.99
Data Source: STRINGDB
Publication Statistics
PubMed Score  2033.84

PubMed score by year
PubTator Score  1173.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: