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Tchem
TRPC6
Short transient receptor potential channel 6

Protein Summary
Description
Thought to form a receptor-activated non-selective calcium permeant cation channel (PubMed:19936226, PubMed:23291369). Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C (PubMed:26892346). Seems not to be activated by intracellular calcium store depletion. The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000344327
  • ENSP00000340913
  • ENSG00000137672
  • ENST00000348423
  • ENSP00000343672
  • ENST00000360497
  • ENSP00000353687

Symbol
  • TRP6
  • TRP6
  • FSGS2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
molecular function
0.9
biological term
0.83
metabolite
0.82
gene perturbation
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 882.48   (req: < 5)
Gene RIFs: 149   (req: <= 3)
Antibodies: 391   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 882.48   (req: >= 5)
Gene RIFs: 149   (req: > 3)
Antibodies: 391   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 32
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
1
1
64
myeloid white cell count
1
1
1
57.7
1
1
0
1.1
41.1
1
1
0
1.1
41.1
platelet crit
1
1
1
18.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
age at menarche
1
64
myeloid white cell count
1
57.7
0
1.1
41.1
0
1.1
41.1
platelet crit
1
18.8
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (39)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Effects of PIP2 hydrolysis
Reactome
Elevation of cytosolic Ca2+ levels
Reactome
G alpha (q) signalling events
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Effects of PIP2 hydrolysis
Elevation of cytosolic Ca2+ levels
G alpha (q) signalling events
Gene Ontology Terms (31)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (106)
1 – 10 of 106
NPHS2
Tbio
Novelty: 0.00212981
Score: 0.99
Data Source: STRINGDB
NPHS1
Tbio
Novelty: 0.00104742
Score: 0.984
Data Source: STRINGDB
RNF24
Tbio
Novelty: 0.11545602
Score: 0.952
Data Source: STRINGDB
KIRREL1
Tbio
Novelty: 0.03216031
Score: 0.949
Data Source: STRINGDB
TRPC1
Tbio
Family: IC
Novelty: 0.00233677
Score: 0.941
Data Source: Reactome,STRINGDB
TRPC5
Tchem
Family: IC
Novelty: 0.00406517
Score: 0.94
Data Source: Reactome,STRINGDB
TRPC4
Tchem
Family: IC
Novelty: 0.00339889
Score: 0.94
Data Source: Reactome,STRINGDB
TRPC3
Tchem
Family: IC
Novelty: 0.00268752
Score: 0.937
Data Source: STRINGDB
TRPC7
Tchem
Family: IC
Novelty: 0.0033307
Score: 0.931
Data Source: STRINGDB
PLCG1
Tchem
Family: Enzyme
Novelty: 0.00110273
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  882.48

PubMed score by year
PubTator Score  503.04

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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